Modulation of oxidative stress induced cerebral ischemia in wistar rats by hydroalcoholic extract oftalinum triangulare (Record no. 17369)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220830143311.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220830b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17673 |
| Author | Mathala, Nalini |
| 245 ## - TITLE STATEMENT | |
| Title | Modulation of oxidative stress induced cerebral ischemia in wistar rats by hydroalcoholic extract oftalinum triangulare |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(2), Apr-June |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 503-510p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Neuroprotection is one of considerable interest in search of novel therapies<br/>to improve ischemic brain damage in the present scenario. The objective of the present<br/>investigation is to study the actions of<br/>Talinum triangulare in cerebral ischemia/reperfusion<br/>induced oxidative stress in Wistar rats and<br/>in-vitro antioxidant actions. Methods: Four<br/>different groups of adult Wistar rats are selected for study where group III and group<br/>IV are treated for 15 days with TTE (200mg/kg, 400mg/kg) earlier to ischemia, on<br/>16 th day rats are dissected through global cerebral ischemia by occlusion of unilateral<br/>common carotid artery, prior to the dissection animals are sedated with thiopentone and<br/>after ischemia induction that 30 min reperfusion was followed. Following the ischemic<br/>injury various parameters such as infarct size, SOD, MDA, CAT and GSH levels were<br/>assessed after 48hr of reperfusion. Results: Phytochemical screening of TTE indicated<br/>the presence of alkaloids, flavonoids, glycosides, carbohydrates, saponins, tannins and<br/>resins<br/>. TTE also showed a significant<br/>in-vitro antioxidant activity. Pre-treatment of TTE<br/>for 15 days prior to the ischemic-reperfusion, the results reported a huge reduction in<br/>reduction in infarct size, MDA levels and significant increase in SOD, CAT and GSH levels<br/>compared to ischemic control rats which was statistically significant. Conclusion: The<br/>present study showed that hydroalcoholic extract of TTE leaves showed a significant<br/>in-vitro and in-vivo antioxidant activity. The present investigation reported that<br/>Talinum<br/>triangulare leaves extract showed dose dependant cerebroprotective effect with the<br/>selected dose of TTE 200 mg/kg and 400 mg/kg. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17674 |
| Co-Author | Rao, Vijaya Bhaskara |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-503.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 30/08/2022 | 2022-1442 | 30/08/2022 | 30/08/2022 | Articles Abstract Database |