Anti-inflammatory and anti-hyperuricemic effect of ficus benghalensis bark extract in raw 246.7 cell line (Record no. 17371)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220830144231.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220830b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17628 |
| Author | Sabi, Essa M. |
| 245 ## - TITLE STATEMENT | |
| Title | Anti-inflammatory and anti-hyperuricemic effect of ficus benghalensis bark extract in raw 246.7 cell line |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(2), Apr-June |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 520-528p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Hyperuricemia and inflammation are associated with the etiology and<br/>pathogenesis of several metabolic diseases. Controlling the elevated levels of uric acid<br/>and inflammation can be a potential therapeutic option for several metabolic diseases.<br/>Aim: The current study examined the anti-inflammatory and anti-hyperuricemic properties<br/>of<br/>Ficus benghalensis bark extract<br/>in vitro using murine macrophage RAW 246.7 cells.<br/>Materials and Methods: Hydroalcoholic extracts of<br/>Ficus benghalensis bark were obtained.<br/>Cytotoxicity and cell viability test of the extracts was evaluated by MTT and Trypan blue<br/>exclusion assay. Cells were microscopically observed for the presence of dead cells. To<br/>explore the anti-inflammatory and anti-hyperuricemic activity, RAW 246.7 cells were<br/>induced with lipopolysaccharide and treated at the concentrations of 20, 40, and 60 μg/ml<br/>of<br/>Ficus benghalensis bark extract and assessed for xanthine oxidase activity, uric acid<br/>levels, reactive oxygen species, lipid peroxidation assay, nitric oxide levels and gene<br/>expression studies of a pro-inflammatory and anti-inflammatory cytokine such as TNF-α<br/>and IL- 10. Results: A dose-dependent reduction in the xanthine oxidase activity when<br/>treated with the bark extract with higher inhibition at 60 μg/ml. Reduction in the amount<br/>of uric acid, ROS, nitric oxide, and lipid peroxidation are similar to xanthine oxidase<br/>activity with a significant decrease in all treated groups and higher reduction at 60 μg/<br/>ml treatment. Gene expression study showed downregulation of TNF-α and upregulation<br/>of IL- 10 in treated groups. Conclusion: Our study demonstrates that<br/>Ficus benghalensis<br/>bark extract exhibits anti-hyperuricemic and anti-inflammatory effects possibly through<br/>xanthine oxidase inhibition. The results provide evidence that<br/>Ficus benghalensis bark<br/>extract may have the potential to treat hyperuricemia and complications related to<br/>hyperuricemia. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17629 |
| Co-Author | Mujamammi, Ahmed H. |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-520.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 30/08/2022 | 2022-1444 | 30/08/2022 | 30/08/2022 | Articles Abstract Database |