Rapid simultaneous quantitative analysis of hypoglycemic agents by RP HPLC: development, validation and application to medicine (Record no. 17376)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220901103813.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220901b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 10005 |
| Author | Attimarad, Mahesh |
| 245 ## - TITLE STATEMENT | |
| Title | Rapid simultaneous quantitative analysis of hypoglycemic agents by RP HPLC: development, validation and application to medicine |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(2), Apr-June |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 564-572p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: For the treatment of diabetes mellitus type 2, a new formulation containing<br/>vildagliptin and remogliflozin was developed. A simple and rapid RP-HPLC method<br/>employing linagliptin as an internal standard was developed for quality control of this<br/>medicine. Methodology: Formulation analytes, including IS, were separated on a Zorbax<br/>C18 column with isocratic elution of acetonitrile and phosphate buffer (pH 5) 55:45 v/v<br/>at a flow rate of 1.2 mL/min. The experiment was carried out at room temperature and<br/>monitored at a wavelength of 210 nm. The approach was also validated in accordance<br/>with the ICH Q2 requirements. Results: The optimized HPLC approach revealed a<br/>satisfactory linearity in the concentration ranges of 10-60 μg/mL and 10-100 μg/mL for<br/>VIL and REM respectively, with good regression coefficient (<br/>R2≥0.998). The average<br/>accuracy for VL and REM was 99.57 percent and 100.59 percent, respectively, with a<br/>low percentage relative error. The method’s precision was proven by the low percentage<br/>relative standard deviation. Furthermore, a robustness assessment employing a Pareto<br/>chart generated using a three-level factor interaction study, a multivariate technique,<br/>demonstrated that minor changes in individual experimental conditions had no effect<br/>on the test results. Finally, the optimized HPLC method was effectively used to assess<br/>VIL and Rem from formulation simultaneously. Conclusion: The findings of an assay<br/>comparing a simple and rapid isocratic RP-HPLC method devised for the simultaneous<br/>quantification of VIL and REM to a previously published approach revealed no significant<br/>differences in the assay results. As a result, it might be utilized in any analytical laboratory<br/>for quality control of this formulation. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17684 |
| Co-Author | Venugopala, Katharigatta Narayanaswamy |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-564.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 01/09/2022 | 2022-1449 | 01/09/2022 | 01/09/2022 | Articles Abstract Database |