In vivo wound healing potential of raloxifene nanoemulsion gel for the management of postmenopausal cutaneous wounds (Record no. 17379)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220901110029.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220901b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17689 |
| Author | Singh, Tej Pratap |
| 245 ## - TITLE STATEMENT | |
| Title | In vivo wound healing potential of raloxifene nanoemulsion gel for the management of postmenopausal cutaneous wounds |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(2), Apr-Jun |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 589-599p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Depletion in estrogen level(s) especially in postmenopausal women is<br/>reported to have delayed wound healing effects; hence we have evaluated the wound<br/>healing potential of raloxifene in rat model. Objectives: Investigating the wound healing<br/>effects of raloxifene nanoemulsion for the management of postmenopausal cutaneous<br/>wounds. Materials and Methods: The optimized nanoemulsion gel contains 0.072%<br/>raloxifene hydrochloride. Female Wistar rats were used to investigate its wound healing<br/>effects. After three months of ovariectomy, wound healing effect was observed in terms<br/>of breaking strength, tensile strength, area of wound contraction, wound closure time,<br/>hydroxyproline content and histopathological changes. Results: The nanoemulsion gel<br/>exhibited better retention (34.31%) than its nanoemulsion. The raloxifene nanoemulsion<br/>gel has no erythema and no eschar formation recorded, and it is safe for topical use.<br/>In the incision wound model in ovariectomized rats, breaking (898±25g) and tensile<br/>strengths (4.47±0.12 g/mm2<br/>) in raloxifene treated groups were found to be higher than<br/>the untreated control group. Additionally, in ovariectomized rats, wound contraction was<br/>found to be 100% in the treated group s following 20 days of post-wounding, where<br/>as in control group only 88% was contraction was observed. Also, more hydroxyproline<br/>content in raloxifene treated ovariectomized rat was observed that recommend more<br/>collagen content than the untreated ovariectomized rat but approximately similar effects<br/>to untreated non-ovariectomized rats. Histopathological studies confirmed that the<br/>raloxifene treated groups had more re-epithelialization, neo-vascularization, fibroblast<br/>proliferation, and collagen deposition than the control group. Conclusion: These results<br/>confirms that the raloxifene nanoemulsion gel has significant wound healing potential,<br/>as observed in ovariectomized rats, which will be helpful in postmenopausal cutaneous<br/>wound healing. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17690 |
| Co-Author | Verma, Navneet |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-589.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 01/09/2022 | 2022-1452 | 01/09/2022 | 01/09/2022 | Articles Abstract Database |