Formulation and evaluation of film forming solution of diphenhydramine hydrochloride for transdermal delivery (Record no. 17594)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220922111327.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220922b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18024 |
| Author | Akhil Baby |
| 245 ## - TITLE STATEMENT | |
| Title | Formulation and evaluation of film forming solution of diphenhydramine hydrochloride for transdermal delivery |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 43-49p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: The present work intends to formulate and evaluate film forming solution of<br/>diphenhydramine. Materials and Methods: Film forming solutions (FFS) for transdermal<br/>delivery of Diphenhydramine HCl were prepared using different polymers (hydroxypropyl<br/>cellulose, Eudragit L 100, polyvinylpyrollidone K30 and polyvinylpyrollidone K90), PEG<br/>400 as plasticizer and ethyl alcohol as solvent. Results: The film forming solutions were<br/>found to display an acceptable drying time ranging from 2 to 5 min.<br/>In-vitro release<br/>studies indicated percentage drug released by the end of 8 h from FFS of HPC-EF,<br/>Eudragit L 100 and PVP K 30 was found to be 41.31 ± 2.1%, 14.81 ± 1.2 % and<br/>25.7 ± 1.9 % respectively. FFS of HPC-EF that readily released drug were considered<br/>for further development by incorporating penetration enhancers like azone, isopropyl<br/>myristate and oleic acid. Steady state flux of drug across shed snake skin used as a<br/>barrier in vertical Franz diffusion cell was found to be 42.27 ±3.5 mg/cm2/hr, 51.18<br/>±4.9 mg/cm2/hr and 57.91 ± 7.2 mg/cm2/hr for FFS containing isopropyl myristate,<br/>oleic acid and azone as permeation enhancers respectively. Conclusion: Considering the<br/>plasma clearance of the drug and transdermal steady state flux, it can be inferred that<br/>FFS containing azone as enhancer needs to be spread across an application area of<br/>0.5 cm2 to elicit a therapeutic response. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18025 |
| Co-Author | Hagalavadi, Nanjappa Shivakumar |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-43_0.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 22/09/2022 | 2022-1696 | 22/09/2022 | 22/09/2022 | Articles Abstract Database |