Development of tapentadol hydrochloride loaded proniosomal gel using main effects screening design and in silico verification using parameter sensitivity analysis (Record no. 17597)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220922120051.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220922b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18031 |
| Author | Sangeetha G. |
| 245 ## - TITLE STATEMENT | |
| Title | Development of tapentadol hydrochloride loaded proniosomal gel using main effects screening design and in silico verification using parameter sensitivity analysis |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 65-76p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: Tapentadol Hydrochloride is a centrally acting opioid analgesic of biopharmaceutical<br/>classification system class I drug. Oral administration of tapentadol hydrochloride<br/>undergoes extensive first-pass metabolism leads to poor bioavailability. The present study<br/>was aimed to screen the critical material attributes to deliver the tapentadol hydrochloride<br/>through the transdermal route using a carrier proniosomal gel. Methodology: Main effect<br/>screening design has been constructed to screen the choice of surfactant used for the<br/>formulation of tapentadol hydrochloride proniosomal gel. The critical material attributes<br/>selected were surfactant, cholesterol, and soya lecithin, with responses entrapment<br/>efficiency (%), vesicle size (nm), and zeta potential (mV). All 24 runs of experiments were<br/>performed and evaluated to check the model fit. The<br/>in silico verification was analyzed<br/>using parameter sensitivity analysis. Results: The prediction profiler showed maximum<br/>desirability for Kolliphore RH 40 against the set goals. The design diagnostic efficiency<br/>was measured better for the constructed MESD. Also, parameter sensitivity analysis<br/>confirms that the vesicle size would play a principal role in the permeation of tapentadol<br/>hydrochloride proniosomal gel. Conclusion: Hence, Kolliphore RH 40 was considered for<br/>the further optimization process. The tapentadol hydrochloride proniosomal gel would be<br/>a better alternative to oral therapy. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18032 |
| Co-Author | Swamivel Manickam, M. |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-65_0.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 22/09/2022 | 2022-1699 | 22/09/2022 | 22/09/2022 | Articles Abstract Database |