Nanostructured lipid carrier: a potential system for enhanced oral bioavailability of felodipine (Record no. 17599)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220922122210.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220922b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 9980 |
| Author | Patil, Archana Sidagouda |
| 245 ## - TITLE STATEMENT | |
| Title | Nanostructured lipid carrier: a potential system for enhanced oral bioavailability of felodipine |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 77-85p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Felodipine is BCS class II drug with poor and variable bioavailability due to<br/>its insolubility in water (19mg/L) and extensive metabolism in liver and gut. Thus, in the<br/>study Nanostructured lipid carriers (NLCs) of Felodipine were formulated to improve its<br/>solubility and bioavailability. Methods: NLCs loaded with Felodipine were prepared by<br/>high shear homogenization with ultrasonication. The NLCs were characterized for particle<br/>size, polydispersity index, entrapment efficiency, content of drug,<br/>in vitro drug release<br/>studies, stability studies and<br/>in vivo bioavailability studies. Results: The mean particle<br/>size and polydispersity index for optimized formulation F2 was found to be 187.0±0.06<br/>and 0.259±0.002 respectively. The drug content achieved was between the ranges of<br/>51.15± 0.01 to 69.14±003% for F1 to F5 formulations. The zeta potential of optimized<br/>formulation was found to be -38.2 mV, which showed good stability. Formulation F2<br/>showed highest percentage entrapment efficiency of 75.15±0.003.<br/>In vitro drug release<br/>studies showed sustained release pattern with maximum drug release of 72.82% by<br/>F2 formulation at the end of 12h. The bioavailability studies demonstrated significant<br/>enhancement in bioavailability of Felodipine NLCs in comparison to marketed product.<br/>Stability studies carried out for optimized formulation F2 showed that the NLCs are more<br/>stable at 4±2°C. Conclusion: Nanostructured lipid carriers loaded with Felodipine were<br/>able enhance the bioavailability of drug by 2.0 folds in comparison to marketed product<br/>and also demonstrated sustained drug release pattern for longer period of time. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18034 |
| Co-Author | Jaknoor, Vinayak |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-77.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 22/09/2022 | 2022-1701 | 22/09/2022 | 22/09/2022 | Articles Abstract Database |