Fabrication and evaluation of gemcitabine-loaded alginate microspheres: a potential approach for treatment of various carcinomas (Record no. 17600)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220922123257.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220922b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18035 |
| Author | Maruf Hossain |
| 245 ## - TITLE STATEMENT | |
| Title | Fabrication and evaluation of gemcitabine-loaded alginate microspheres: a potential approach for treatment of various carcinomas |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 86-93p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim/background: Microspheres are spherical particles, having a core, having a particle size<br/>of 1μm to 1000μm. They are advantageous as compared to conventional dosage forms<br/>of drugs, in parameters like sustainability and control of drug release, drug protection,<br/>biodegradability, targeting ability and many more. Gemcitabine is a prodrug and is used<br/>in various carcinomas. Sodium Alginate and Ethyl Cellulose are used as polymers. The<br/>fabrication aims to sustain the drug release which can treat pancreatic, breast, ovarian<br/>and lung cancer. Materials and Methods: Microspheres have been made by Ionotropic<br/>Gelation method, Sodium alginate, Ethyl cellulose and Calcium chloride. Weighed quantity<br/>of drug and polymer were added to sodium alginate solution, which was then added drop<br/>wise to Calcium chloride solution under continuous stirring to procure spherical rigid<br/>microspheres. These were then subjected to various physicochemical characterizations<br/>and surface analysis. Results and Conclusion: Results have shown that by increasing<br/>the polymer concentration, entrapment efficiency and drug loading have also increased.<br/>Particle size, SEM and micromeritic evaluation have exhibited satisfactory results. The<br/>drug release studies depict that most of the batches have showed less than 10% release<br/>acid media so it protects the drug from the upper part of GI Tract. These attributes prove<br/>that microsphere technology, being a crucial novel drug delivery system can be very<br/>effective in reducing dose frequency, dose dumping and better patient compliance. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18036 |
| Co-Author | Chatterjee, Shayeri |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-86.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 22/09/2022 | 2022-1702 | 22/09/2022 | 22/09/2022 | Articles Abstract Database |