Development and evaluation of nanosuspension incorporated in situ gel of brimonidine tartarate for ocular drug delivery (Record no. 17602)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220922141719.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220922b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18039 |
| Author | Hanagandi, Viresh |
| 245 ## - TITLE STATEMENT | |
| Title | Development and evaluation of nanosuspension incorporated in situ gel of brimonidine tartarate for ocular drug delivery |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 94-102p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objectives: The goal of the study was to develop, optimize and<br/>in vitro-<br/>ex vivo<br/>investigation of Brimonidine tartrate nanosuspension incorporated<br/>in situ gel formulation<br/>to differentiate with marketed (formulation) eye drops for the efficient treatment of<br/>glaucoma. Materials and Methods: Nanosuspensions were formulated by solvent<br/>evaporation method using probe sonication technique. The effect of the independent<br/>variables Tween 80 and Pluronic F68 concentration on Nanosuspension properties were<br/>investigated by performing 32 factorial design of experiment. Nanosuspensions were<br/>characterized by measuring particle diameter and zeta potential, surface morphology,<br/>drug entrapment efficiency and then nanosuspensions were incorporated in to<br/>in situ gel<br/>base for<br/>in vitro release and<br/>ex-vivo corneal permeability studies and were differentiated<br/>with marketed product. Results and Discussion: The most excellent nanosuspension<br/>formulation system selected via the Design Expert 12 software program was F7 which<br/>contains 0.5% of Tween 80 and 3 % of Pluronic F68. An optimized nanosuspension<br/>formulation F7 showed an average particle diameter of 157.4±0.95 nm with PDI of<br/>0.379 and a zeta potential of -19.1 mV. It had an average entrapment efficiency of<br/>85.95±1.40%. It also showed 98.36±0.58% of drug being released<br/>in vitro when<br/>incorporated in to<br/>in situ gel base over 24 hr. F7 showed significantly greater drug<br/>permeation in comparison to the marketed eye drop formulation in<br/>ex vivo transcorneal<br/>permeability studies and was able of retaining its stability for 90 days. Conclusion: The<br/>developed nanosuspension incorporated<br/>in situ gel base formulation could be utilized as<br/>potential delivery system for long time management of glaucoma with once daily dose. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4755 |
| Topical term or geographic name entry element | PHARMACOGNOSY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 9980 |
| Co-Author | Patil, Archana Sidagouda |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-94.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 22/09/2022 | 2022-1704 | 22/09/2022 | 22/09/2022 | Articles Abstract Database |