Formulation and evaluation of natamycin solid dispersion incorporated ophthalmic films (Record no. 17603)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220922144147.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220922b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18040 |
| Author | Bhandari, Lavanya |
| 245 ## - TITLE STATEMENT | |
| Title | Formulation and evaluation of natamycin solid dispersion incorporated ophthalmic films |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 103-111p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: The aim of this study was to enhance the solubility of Natamycin, an anti-<br/>fungal agent used in fungal keratitis, through solid dispersion incorporated ophthalmic<br/>films with the purpose to avoid frequent dosing, enhance the period of retention, and<br/>sustaining release for better patient compliance. Materials and Methods: Firstly, solid<br/>dispersions were prepared by the solvent evaporation method and then, the best solid<br/>dispersion formulation was incorporated into films which were prepared by the solvent<br/>casting method using retarding polymers Ethyl cellulose, PVA and Chitosan. PEG-400<br/>was used as a plasticizer. The films were evaluated for their thickness, surface pH, drug<br/>content, weight uniformity, folding endurance, tensile strength, antimicrobial activity,<br/>in-vitro and<br/>ex-vivo permeation studies, and<br/>in-vitro antifungal studies. Results and<br/>Discussion: The films exhibited good mechanical properties with promising results and<br/>were in an acceptable range. The optimized formulation NF6 shows more drug release in<br/>in-vitro studies as compared to<br/>ex-vivo. This is due to the varying pore size of the cornea<br/>and disturbance of other tissues. An ocular irritation test revealed that the prepared<br/>formulation was non-irritant. Conclusion: Thus, the formulated ophthalmic film seems to<br/>be a promising formulation for the safe and effective delivery of Natamycin through the<br/>ocular route in the treatment of fungal keratitis. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4755 |
| Topical term or geographic name entry element | PHARMACOGNOSY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18041 |
| Co-Author | Patil, Archana S. |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-103_2.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 22/09/2022 | 2022-1705 | 22/09/2022 | 22/09/2022 | Articles Abstract Database |