Solid dispersion of lumefantrine using soluplus® by solvent evaporation method: formulation, characterization and in-vitro antimalarial screening (Record no. 17606)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220922151121.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220922b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18043 |
| Author | Kanojiya, Pranita Sunil |
| 245 ## - TITLE STATEMENT | |
| Title | Solid dispersion of lumefantrine using soluplus® by solvent evaporation method: formulation, characterization and in-vitro antimalarial screening |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 121-132p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objectives: Lumefantrine (LUM) is an antimalarial drug having poor aqueous solubility.<br/>The objective was to formulate the solid dispersion of LUM and improve the solubility<br/>and dissolution rate. Materials and Methods: Solvent evaporation technique was used<br/>to prepare solid dispersions (SDs) with Soluplus® (SOL) using a rotary evaporator. The<br/>feasibility of the formation of SD for LUM and SOL was assessed by the Hansen solubility<br/>parameter. The drug solubility was analyzed by the HPLC method and the ratio of LUM:<br/>SOL was optimized to 1:2. The SD was characterized by DSC, FTIR, XRD and SEM.<br/>Results: The results showed that the LUM and SOL had groups that lead to the interaction<br/>between them and this led to conversion from crystalline to amorphous form and thus<br/>improved the dissolution rate. The solubility of L2 was found to be 135 ± 3.3 μg/mL<br/>using the selected dissolution media (0.1 N HCl+1% Myrj 52). The<br/>in-vitro antimalarial<br/>screening was performed using the<br/>P. falciparum 3D7 strain and the<br/>in-vitro cytotoxicity<br/>test was performed using the Vero cell line. The higher antimalarial efficacy of L2 SD<br/>was observed as compared to plain LUM. The selectivity index value of LUM SD depicted<br/>its non-toxicity. Stability study was carried out for three months and the SDs were<br/>evaluated for the drug content, change in weight and<br/>in-vitro drug release. No significant<br/>changes were observed after three months in the drug content, SD weight and<br/>in-vitro<br/>drug release. Thus the L2 SD was found to be stable. Conclusion: The prepared SD<br/>improved the solubility as well as the dissolution rate of the drug. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 16877 |
| Co-Author | Charde, Yogita |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-121.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 22/09/2022 | 2022-1707 | 22/09/2022 | 22/09/2022 | Articles Abstract Database |