Preparation and in-vitro / in-vivo characterization of transdermal amphiphilogel loaded with biodegradable polymeric submicron carriers of meloxicam for treatment of inflammation (Record no. 17613)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220922160202.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220922b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18050 |
| Author | Singhavi, Dilesh Jagdish |
| 245 ## - TITLE STATEMENT | |
| Title | Preparation and in-vitro / in-vivo characterization of transdermal amphiphilogel loaded with biodegradable polymeric submicron carriers of meloxicam for treatment of inflammation |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 133-143p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: The main purpose for this study was to develop and evaluate amphiphilogels loaded<br/>with meloxicam-submicron particles considering the benefits of the transdermal route of<br/>administration of anti-inflammatory drugs (nonsteroidal). Materials and Methods: Glyceryl<br/>monostearate (7%, 9% and 11% w/w) and sorbiton monostearate (span 60; 21%, 23%<br/>and 25% w/w) amphiphilogels containing meloxicam-submicron particles equivalent to<br/>0.5% w/w drug were formulated. Then these were evaluated through rheological,<br/>in-vitro<br/>permeation,<br/>in-vitro release, pharmacokinetics, pharmacodynamics and skin irritation<br/>studies. The rodents were chosen as subjects to conduct the pharmacokinetics study of<br/>meloxicam via oral administration and transdermally as solutions and gels, respectively.<br/>Results: It was observed that the Cmax value of drug obtained from meloxicam solution<br/>and a marketable piroxicam gel formulation were radically lower than that obtained<br/>from an amphiphilogel (FM4, containing 7% w/w glyceryl monostearate). It was also<br/>observed that when applied transdermally, the bioavailability of meloxicam from FM4<br/>was higher (<br/>n = 3,<br/>p< 0.001) than 2.5 times the bioavailability of meloxicam from a<br/>solution which was orally administered. The anti-inflammatory property of FM4 was<br/>comparatively much greater than the commercially available formulations in carrageenan-<br/>induced edema in rat’s paw. Conclusion: It can be concluded that the amphiphilogels<br/>loaded with meloxicam-submicron particles was found to be a safe and efficient drug<br/>delivery system for enhanced transdermal delivery of meloxicam. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18051 |
| Co-Author | Yeole, Pramod |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-133.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 22/09/2022 | 2022-1709 | 22/09/2022 | 22/09/2022 | Articles Abstract Database |