Solid dispersion of artemether in fast disintegrating tablet to enhance dissolution rate and oral bioavailability (Record no. 17615)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220922161819.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220922b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18043 |
| Author | Kanojiya, Pranita Sunil |
| 245 ## - TITLE STATEMENT | |
| Title | Solid dispersion of artemether in fast disintegrating tablet to enhance dissolution rate and oral bioavailability |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 153-165p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objectives: Artemether (ART), an antimalarial drug, have poor solubility and low<br/>bioavailability. Therefore, solid dispersion of the drug was formulated using Soluplus<br/>(SOL) and was incorporated in the fast disintegrating tablet. Materials and Methods:<br/>The solid dispersion (SD) was prepared using the solvent evaporation method using a<br/>rotary evaporator. The optimized SD was evaluated and then incorporated into the tablet.<br/>Results: Solubility studies revealed that ART SD A3 of ratio 1:3 (ART: SOP) showed a<br/>significantly higher solubility and dissolution rate than plain ART. FTIR results indicated<br/>that there was no incompatibility between the drug and hydrophilic carrier. The DSC<br/>as well as XRD studies indicated the transformation from crystalline state of drug into<br/>the amorphous form. SEM studies revealed the deposition of ART on the surface of the<br/>hydrophilic carrier.<br/>In-vitro antimalarial activity was improved of the ART due to the SD<br/>formulation. Fast disintegrating tablet of ART SD A3 was produced by using directly<br/>compressible excipients such as Ludiflash and Ludipress. Ludiflash containing tablet<br/>showed fast disintegration with higher drug release. The pharmacokinetic study in mice<br/>showed increased Cmax and AUC0–24 by 1.88- and 3.19-fold as compared to those of plain<br/>drug. Conclusion: The prepared SDs using SOP provided a platform for increased solubility<br/>and also improved the bioavailability of ART with feasibility for tablet formulation. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18055 |
| Co-Author | Charde, Yogita Manohar |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-153.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 22/09/2022 | 2022-1711 | 22/09/2022 | 22/09/2022 | Articles Abstract Database |