Effect of ocimum sanctum in sodium fluoride (NaF) induced fluorosis in rats: a study with respect to antioxidant enzymes and fluorosis markers (Record no. 17617)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220923095839.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220923b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18063 |
| Author | Shanmugam, Kondeti Ramudu |
| 245 ## - TITLE STATEMENT | |
| Title | Effect of ocimum sanctum in sodium fluoride (NaF) induced fluorosis in rats: a study with respect to antioxidant enzymes and fluorosis markers |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 175-183p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Fluoride contamination was observed in groundwater’s of India, Pakistan,<br/>China, Indonesia and several other countries. In India the states like Andhra Pradesh,<br/>Telangana, Rajasthan, Haryana etc are contaminated with fluoride. Approximately<br/>68 million people are suffering from fluorosis in India. The current study was done to know<br/>the antioxidant effect, anti-fluorosis and free radical scavenging property of<br/>Ocimum<br/>sanctum (OS). Methods: Superoxide dismutase (SOD), glutathione peroxidase (GPx),<br/>glutathione (GSH), glutathione reductase (GR), glutathione-s-transferase (GST), catalase<br/>(CAT), malondialdehyde (MDA), alanine aminotransferase (AAT), alkaline phosphatase<br/>(ALKP), aspartate aminotransferase (AST) and flurosis markers phosphorus (P4<br/>) and<br/>calcium (Ca) are estimated in all groups. 1,1-diphenyl-2-picryl hydrazyl radical (DPPH),<br/>hydroxyl radical, hydrogen peroxide (H 2O2<br/>), Gas chromatography–mass spectrometry<br/>(GC-MS) was analyzed in methanolic extract of<br/>Ocimum sanctum. Results: SOD,<br/>GR, GSH, GPx CAT, activities and Ca levels are decreased in sodium fluoride (NaF)<br/>intoxicated rats. Whereas MDA, ALKP AST, AAT, and P4 levels are increased in NaF<br/>rats. However,<br/>Ocimum phenolic fraction treatment normalized the antioxidant enzymes,<br/>hepatic markers and flurosis markers in NaF intoxicated rats. DPPH, H 2O2 and hydroxyl<br/>radical of ocimum posses potent free radical scavenging activities. GC – MS studies of<br/>Ocimum sanctum showed the presence of many bioactive compounds like Caryophyllene<br/>oxide, 2-(2-Propenyl)-m-anisidine, 2H-Pyan-2-one, 5,6-Dihydro-4-(2-methyl-3-methylene-<br/>1-buten-4-yl etc. Further, histopathological observations prove that ocimum protects<br/>the hepatic tissue from NaF intoxication. Conclusion: Our study proves that<br/>Ocimum<br/>sanctum phenolic fraction protects the hepatic tissue from Na F induced fluorosis in rats.<br/>Key words:<br/>Ocimum sanctum, Antioxidant Enzymes, Fluorosis markers, Liver markers,<br/>GC-MS analysis, Rats. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18064 |
| Co-Author | Shanmugam, Bhasha |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-175.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 23/09/2022 | 2022-1714 | 23/09/2022 | 23/09/2022 | Articles Abstract Database |