Evaluation of hepatoprotective potential of stem bark of neolamarckia cadamba against chloroform and over dose of iron dextran induced hepatotoxicity in experimental swiss albino mice (Record no. 17619)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220923113255.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220923b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18067 |
| Author | Das, Saumya |
| 245 ## - TITLE STATEMENT | |
| Title | Evaluation of hepatoprotective potential of stem bark of neolamarckia cadamba against chloroform and over dose of iron dextran induced hepatotoxicity in experimental swiss albino mice |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 191-198p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: In general, use of herbal medicines are considered as the backbone in<br/>traditional system of medicines as it has been used for food, flavoring agents and in the<br/>form of medicines. Keeping in knowledge the increasing demand of herbal drugs over their<br/>synthetic counter parts and to restrain the worldwide problem of multidrug resistance<br/>(MDR) in hepatoprotective activity.<br/>Neolamarckia cadamba that is commonly called<br/>Cadamb is a standout amongst the most significant therapeutic plants having a place<br/>with the Rubiaceae family. It is one of such Ayurvedic cure that has been referenced in<br/>numerous Indian restorative written works. The arrangement of work includes gathering<br/>and confirmation of stem bark of cadamb plant pursued by shade drying, granulating,<br/>and extraction by two-fold cool maceration, phytochemical examination lastly screening<br/>of pharmacological exercises as expressed. Aim: The present study was carried out to<br/>establish hepatoprotective activity of hydro alcoholic extract of stem bark of<br/>Neolamarckia<br/>cadamba by using two established hepatotoxic screening models in Swiss albino<br/>mice (chloroform induced hepatotoxicity and iron over dose induced hepatotoxicity).<br/>Materials and Methods: The hepatoprotective activity of<br/>Neolamarckia cadamba was<br/>screened by hydro alcoholic extract of stem bark of<br/>Neolamarckia cadamba (NCHAE).<br/>The experimental animals were treated with corn oil and chloroform for a period of<br/>7 days at a dose of 0.75mg/kg body weight, p.o to induce hepatotoxicity. In the second<br/>experimental model over dose of iron dextran induced hepatic damage was performed<br/>by administering 100 mg/kg, i.p.upto7 days, 3 consecutive periods. Blood samples were<br/>collected for the estimation of biochemical parameters and histopathological changes<br/>in liver was also performed. Silymarin (50 mg/kg; body weight) was used as standard<br/>referral of hepatoprotective agent. Results: Chloroform and iron over dose treatment<br/>were induced higher levels of liver marker enzymes and showed damage of hepatocytes.<br/>In histopathological findings there were significant opposed treatment with<br/>Neolamarckia<br/>cadamba dose dependently. The results indicated that biochemical changes produced<br/>by both the hepatotoxicity models were restored to normal by NCHAE. In the present<br/>study, the results of NCHAE was found significant hepatoprotective effect (***<br/>p<0.01)<br/>against both the inducing agents, which was indicated by the enhancement in biochemical<br/>parameters. Conclusion: The current study confirmed the hepatoprotective effect<br/>of NCHAE against the chloroform induced hepatotoxicity and iron over dose induced<br/>hepatotoxicity models and the activity is likely related to its potent antioxidant and iron-<br/>chelating property. NCHAE therefore needs to be for further in-deep studies to correlate<br/>its bioactive constituents responsible for the pharmacological activity selected. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4755 |
| Topical term or geographic name entry element | PHARMACOGNOSY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18068 |
| Co-Author | Shakya, Richa |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-191.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 23/09/2022 | 2022-1716 | 23/09/2022 | 23/09/2022 | Articles Abstract Database |