In silico and molecular docking studies of black pepper phyto-constituents against emrd efflux pump of E. coli (Record no. 17620)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220923114117.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220923b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18069 |
| Author | Dongre, Prerana |
| 245 ## - TITLE STATEMENT | |
| Title | In silico and molecular docking studies of black pepper phyto-constituents against emrd efflux pump of E. coli |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 199-206p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Multidrug resistance (MDR) bacterial infection is the next pandemic waiting behind the<br/>COVID-19 with annual mortality rate 700000 worldwide. Among the MDR bacteria,<br/>Escherichia coli,<br/>Staphylococcus aureus,<br/>Klebsiella pneumoniae,<br/>Acinetobacter<br/>baumannii,<br/>Pseudomonas aeruginosa,<br/>Enterococcus faecium and<br/>Enterococcus faecalis<br/>are showing average resistance of 50 to 80% to ampicillin, amoxicillin, third-generation<br/>cephalosporin’s and fluoroquinolone and even to combinations antibiotics such as<br/>amoxicillin-clavulanic acid. To make the antibiotic resistance issue worst, pharmaceutical<br/>industry is reluctant to invest in research and development of new antibiotic typically<br/>due to low returns on investment. Accordingly, use of combination of two or more<br/>antibiotics or use of the antibiotic adjuvants are only available ways in combatting the<br/>ever growing Multidrug resistance (MDR) in bacteria. The present paper is designed to<br/>analyze the synergistic potential of black pepper phyto-constituents as the amoxicillin<br/>adjuvants in comparison with isolated piperine against the MDR<br/>E. coli. using<br/>in-silico<br/>molecular docking. The result indicates that binding energy (Kcal/mol) and torsion free<br/>energy (Kcal/mol) of piperine (-6.23, +0.89), beta caryophyllene (-6.36, +0.00), beta<br/>selinene (-6.93, +0.30), beta-Thujene (-5.42, +0.30) is less for the emrD efflux pump as<br/>compared to amoxicillin (-5.85, +2.93) respectively indicating strong inhibition for EmrD<br/>of MDR<br/>E-coli than amoxicillin. The results are also indicating that black pepper extract<br/>containing all aforementioned phyto-constituents has synergistic effect in comparison<br/>with isolated piperine against the MDR<br/>E. coli. ADMET of these phyto-constituents also<br/>indicates their safety profile in combination with amoxicillin. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4755 |
| Topical term or geographic name entry element | PHARMACOGNOSY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18071 |
| Co-Author | Bhambar, Rajendra |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-199.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 23/09/2022 | 2022-1717 | 23/09/2022 | 23/09/2022 | Articles Abstract Database |