Hydroxychloroquine metabolites – an exploratory computational study (Record no. 17624)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220923115316.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220923b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18072 |
| Author | Islam, Mohammed Monirul |
| 245 ## - TITLE STATEMENT | |
| Title | Hydroxychloroquine metabolites – an exploratory computational study |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 215-223p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: HCQ has been found to provide the immunomodulation that helps to<br/>abate the possible cytokine storm response caused by the SARS COVID-19 virus and<br/>subsequent failures of major organs. It is also being used historically in treating Malaria and<br/>Rheumatoid arthritis and is known to be useful in cancer treatment. However, it shows<br/>a half-life of up to 70 days and has severe adverse effects including gastric disorders<br/>and retinopathy. Hypothesis: Therefore, we propose to explore some of its metabolites/<br/>intermediates namely Desethyl hydroxychloroquine (DHCQ), Desethyl chloroquine (DCQ),<br/>and Bis-desethyl chloroquine (BDCQ) as alternate drug systems with minimized toxicity.<br/>Results and Discussion: The structural and spectral studies of these lead compounds<br/>to be unraveled using computational modeling and the evaluation of ADME parameters<br/>such as absorption, distribution, metabolism, and excretion would be performed using<br/>the SwissADME tool to assess the drug-likeness and medicinal chemistry friendliness.<br/>The future scope of the work involves the docking studies of these compounds to assess<br/>the therapeutic compliance for the treatment of viral infections and rheumatoid arthritis. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18073 |
| Co-Author | Singh, Purna Sivarama |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-215.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 23/09/2022 | 2022-1719 | 23/09/2022 | 23/09/2022 | Articles Abstract Database |