Development of validated stability indicating method for estimation of vandetanib and characterization of its degradants by LC-ESI-MS (Record no. 17629)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220923122520.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220923b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18077 |
| Author | Salode, Vikrant Liladhar |
| 245 ## - TITLE STATEMENT | |
| Title | Development of validated stability indicating method for estimation of vandetanib and characterization of its degradants by LC-ESI-MS |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 232-239p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: In the current study, stability indicating high performance liquid chromatography<br/>method (RP-HPLC) was developed and validated for the determination of Vandetanib,<br/>also its major degradants were identified and characterized by Liquid Chromatography-<br/>Tandem Mass spectrophotometric method (LC-ESI-MS). Methods and Materials: This<br/>method was developed on Nucleosil 100-5, C18 (250×4.6 mm, 5μm) column by using<br/>Methanol: Ammonium acetate buffer as Mobile phase in the ratio, 90:10 v/v, having flow<br/>rate of 1 ml/min. The estimation was carried out at 249 nm. Further Vandetanib was<br/>subjected to various stress condition like acidic, alkali, oxidative, thermal and photolytic<br/>degradation. The degradation pathways for major degradants were idenitifed. Results:<br/>The method was developed and validated for linearity, robustness, accuracy, precision,<br/>linear regression analysis data which indicates the good linear relationship, correlation<br/>coefficient was found 0.992 in the concentration range of 1-10 μg/ml. In the stress<br/>results, the degradation of drug in alkaline, as well as acidic medium showed significantly.<br/>The product degradation was characterized by the LC-MS technique. Conclusion: The<br/>developed method was found to be rapid, sensitive, accurate, precise, and robust for the<br/>analysis of Vandetanib by which routine analysis of drugs can be done. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18078 |
| Co-Author | Game, Madhuri Deorao |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-232.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 23/09/2022 | 2022-1721 | 23/09/2022 | 23/09/2022 | Articles Abstract Database |