Antiepileptic‑drug tapering and seizure recurrence: Correlation with serum drug levels and biomarkers in persons with epilepsy (Record no. 18265)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20221118095549.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221118b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 19127 |
| Author | Sarangi, Sudhir C. |
| 245 ## - TITLE STATEMENT | |
| Title | Antiepileptic‑drug tapering and seizure recurrence: Correlation with serum drug levels and biomarkers in persons with epilepsy |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.54(1), Jan-Feb |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Wolter Kluwer |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 24-32p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | OBJECTIVES: Antiepileptic‑drug (AED) serum level and inflammatory biomarkers are primarily<br/>monitored/assessed during epilepsy treatment for effective seizure control; however, their correlation<br/>with seizure recurrence (SR) following AED‑tapering has not been established, and this is being<br/>investigated in this study.<br/>MATERIALS AND METHODS: This prospective observational study enrolled persons with<br/>epilepsy (PWE) on AED monotherapy and going to start tapering after being seizure‑free for ≥2 years.<br/>Data regarding seizure episodes, AED‑treatment, and adverse events (using Liverpool Adverse<br/>Event profile [LAEP]‑score) were recorded. Serum AED levels using high‑performance liquid<br/>chromatography and biomarkers levels through enzyme‑linked immunosorbent assay kits were<br/>estimated at AED‑tapering commencement and at 6 months/SR time.<br/>RESULTS: Among 129 enrolled PWE (levetiracetam [n = 52], valproate [n = 34], carbamazepine [n = 29],<br/>and phenytoin [n = 14]), SR occurred in 23.3% during follow‑up (range 12–44 months). PWE<br/>with subtherapeutic serum AED level at the onset of tapering had higher SR (P = 0.004) than<br/>those with therapeutic or higher levels. Levetiracetam‑treated PWEs with SR have significantly<br/>low AED levels than PWE with no‑SR (P < 0.001). PWE had significantly raised inflammatory<br/>biomarkers (interleukin [IL]‑1 β, tumor necrosis factor [TNF]‑α, IL‑6, and high-mobility group<br/>box protein 1) and decreased IL‑10 than healthy control subjects. SR and no‑SR groups did not<br/>differ significantly in inflammatory markers except for higher IL‑1 β and TNF‑α levels in SR group<br/>(P = 0.001, 0.02, respectively). Improvement in LAEP score was observed in follow‑up visits without<br/>any difference between SR and no‑SR groups.<br/>CONCLUSION: Low serum AED levels (especially levetiracetam) and raised levels of TNF‑α and<br/>IL‑1 β during tapering commencement had a higher association with SR following AED‑tapering. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 11256 |
| Co-Author | Sachin Kumar |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Andheri - Mumbai Wolters Kluwer India Private Limited |
| International Standard Serial Number | 0253-7613 |
| Title | Indian Journal of Pharmacology |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijp-online.com/temp/IndianJPharmacol54124-157262_042206.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 18/11/2022 | 2022-2148 | 18/11/2022 | 18/11/2022 | Articles Abstract Database |