Neuroprotective effects of linagliptin in a rotenone‑induced rat model of Parkinson’s disease (Record no. 18272)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20221118111958.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221118b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 19138 |
| Author | Abhangi, Kinjal V. |
| 245 ## - TITLE STATEMENT | |
| Title | Neuroprotective effects of linagliptin in a rotenone‑induced rat model of Parkinson’s disease |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.54(1), Jan-Feb |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Wolter Kluwer |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 46-50p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The present study investigates the antiParkinsonian activity of dipeptidyl peptidase‑4 (DPP‑IV) inhibitor,<br/>linagliptin. The experimental Parkinson’s disease (PD) was induced by administration of rotenone at a<br/>dose of 1.5 mg/kg at alternate day subcutaneously for 21 days. Standard drug (levodopa‑200 mg/kg<br/>and carbidopa‑50 mg/kg) and treatment drug (linagliptin‑5 mg/kg, 10 mg/kg, and 20mg/kg) were<br/>administered orally daily 1 h before rotenone administration. In a rat rotenone model, linagliptin<br/>improved muscle coordination, motor performance, and corrected akinesia. Pretreatment with<br/>linagliptin showed significant higher levels of superoxide dismutase, catalase, and glutathione in<br/>brain homogenate of animals. Linagliptin significantly elevated the levels of striatal DA and active<br/>glucagon‑like peptide 1 in brain homogenate of animals. Furthermore, linagliptin amended alterations<br/>induced by rotenone in the thiobarbituric acid reactive substances and inflammatory marker such as<br/>tumor necrosis factor‑α level. The results of the present study indicate the neuroprotective potential<br/>of linagliptin for the management of PD might be due to remarkable improvement in motor functions,<br/>antioxidant, anti‑inflammatory, anti‑apoptotic, and neuroprotective mechanisms. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 19139 |
| Co-Author | Patel, Jigneshkumar Ishwarlal |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian Journal of Pharmacology |
| International Standard Serial Number | 0253-7613 |
| Place, publisher, and date of publication | Andheri - Mumbai Wolters Kluwer India Private Limited |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijp-online.com/temp/IndianJPharmacol54146-1911584_051835.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 18/11/2022 | 2022-2151 | 18/11/2022 | 18/11/2022 | Articles Abstract Database |