Sinonasal mucormycosis and liposomal amphotericin B: A quest for dose optimization (Record no. 18278)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20221118145812.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221118b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 19148 |
| Author | Smile Kajal |
| 245 ## - TITLE STATEMENT | |
| Title | Sinonasal mucormycosis and liposomal amphotericin B: A quest for dose optimization |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.54(2), Mar-Apr |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Wolter Kluwer |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 90-96p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | OBJECTIVES: Sinonasal mucormycosis is a serious fungal infection. Early diagnosis and prompt<br/>antifungal therapy along with surgical intervention is the key to its management. Liposomal<br/>amphotericin B (LAmB) given intravenously is the antifungal agent of choice. However, the current<br/>literature is not clear on its optimum dosage. We did a retrospective study to find the optimum dose<br/>of LAmB in cases with sinonasal mucormycosis.<br/>MATERIALS AND METHODS: Thirty patients diagnosed with mucormycosis involving sinonasal,<br/>rhino‑orbital, or rhino‑orbito‑cerebral regions and receiving only LAmB as pharmacotherapy were<br/>included in our retrospective study from 2017 to 2020. A multiple logistic regression model was<br/>developed to correlate the total dose of LAmB and other parameters with the final outcome which<br/>was defined clinico‑radiologically as improved, worsened, or death. The dose of LAmB which led to<br/>the first significant change in urea, creatinine, and potassium levels was also determined.<br/>RESULTS: The model showed a good fit in goodness‑to‑fit analysis (Pearson = 0.999,<br/>deviance = 0.995), while the likelihood ratio was statistically significant (0.001). The overall model<br/>prediction was 83.3%. However, the correlation of outcome with any of the variables, including mean<br/>LAmB dose per kilogram (82.2 ± 13.02 mg/kg), was statistically not significant.<br/>CONCLUSION: Many patient‑related factors (such as age, comorbidities, extent of the disease, and<br/>side effects from LAmB therapy), which vary on a case‑to‑case basis, contribute to the outcome in a<br/>mucormycosis patient. The optimum dose of LAmB for improved outcome still requires individualization<br/>guided by experience, till well‑designed studies address the question. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4774 |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 19149 |
| Co-Author | Syed, Shariq Naeem |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Andheri - Mumbai Wolters Kluwer India Private Limited |
| Title | Indian Journal of Pharmacology |
| International Standard Serial Number | 0253-7613 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijp-online.com/temp/IndianJPharmacol54290-3381905_092339.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 18/11/2022 | 2022-2157 | 18/11/2022 | 18/11/2022 | Articles Abstract Database |