Dual-pulse release system of atenolol: preparation and in-vitro characterization (Record no. 18655)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20230111151032.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 230111b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 19667 |
| Author | Kunjekar, Sonam Sanjayrao |
| 245 ## - TITLE STATEMENT | |
| Title | Dual-pulse release system of atenolol: preparation and in-vitro characterization |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(4), Oct-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Bangalore |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 1025-1030p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: Hypertension exhibits a circadian rhythm and drugs need to be released at the time<br/>when the blood pressure is elevated most. This elevation is pronounced at 7 pm and at 4<br/>am. Atenolol is an anti-hypertensive drug with an absorption window mainly in the upper<br/>section of the gastrointestinal tract. The present investigation was aimed at designing<br/>floating pulsatile capsules for dual release of atenolol in the stomach for effective<br/>management of hypertension. Materials and Methods: The floating pulsatile capsules<br/>designed had different components: a formaldehyde-treated capsule body; an untreated<br/>cap; a polymer plug layer, containing a polymer; two atenolol-containing immediate-<br/>release tablets and a swellable polymer layer. The polymer plug layer was made of<br/>hydroxypropyl methylcellulose (K4M or E50) and xanthan gum alone or in combination.<br/>The capsules were characterized for weight variation, percent drug content,<br/>in-vitro<br/>release behaviour and floating property. Results: The outcomes of the<br/>in-vitro studies<br/>showed that lag duration between the two pulses of drug release from the formulations<br/>can be adjusted by manipulating the composition of the plug layer. The optimized floating<br/>pulsatile capsule provided the first pulse of the drug immediately after administration to<br/>cover the first point of the symptoms. It provided the drug release from second pulse<br/>after a lag time of 8 hr for covering up the second point of the symptoms in the early<br/>morning. Conclusion: Thus, the dual-release floating pulsatile capsule designed may be<br/>used for chronological treatment of hypertension. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18050 |
| Co-Author | Singhavi, Dilesh Jagdish |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-4-1025.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 11/01/2023 | 2023-0099 | 11/01/2023 | 11/01/2023 | Articles Abstract Database |