Co-administration of coenzyme Q10 and HMG-CoA reductase inhibitor attenuates oxidative stress, TGF-β, TNF-α, nitrite content and MPO levels against experimentally-induced diabetic nephropathy in rats (Record no. 18663)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20230112150949.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 230112b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 19678 |
| Author | Maheshwari, Rajesh A. |
| 245 ## - TITLE STATEMENT | |
| Title | Co-administration of coenzyme Q10 and HMG-CoA reductase inhibitor attenuates oxidative stress, TGF-β, TNF-α, nitrite content and MPO levels against experimentally-induced diabetic nephropathy in rats |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(4), Oct-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Bangalore |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 1091-1098p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objectives: Diabetes is a major disease that causes a tremendous economic burden<br/>internationally. To tackle this horrible condition, good therapeutic intervention with<br/>nutraceutical is required. These include diabetic nephropathy, which ranges from chronic<br/>kidney disease to end-stage renal failure. Thus, this study used nutraceutical such<br/>coenzyme Q10 and HMG-CoA reductase inhibitor (rosuvastatin) to see how beneficial<br/>they are in treating diabetic nephropathy. Materials and Methods: The animal experiments<br/>were conducted to induce nephropathy by using streptozotocin-nicotinamide. Animals<br/>were divided into five groups such as control, diabetic control, coenzyme Q10,<br/>rosuvastatin and their combination. The renal function test was conducted by estimating<br/>uric acid, creatinine and urea. Antioxidant parameters were assessed by evaluating MDA,<br/>SOD, GSH and catalase activity in renal tissue. Levels of MPO, TGF-β, TNF-α and nitrite<br/>concentration were measured together with alterations in histopathology in the kidneys<br/>were observed in every treated animal. Results: Diabetic rats were studied for signs of<br/>nephropathy, and the results showed elevated levels of urea, creatinine, uric acid, MPO<br/>activity, TGF-β, TNF-α, nitrite and MDA as well as decreased levels of GSH, SOD and CAT<br/>activity. It was shown that when coenzyme Q10 and rosuvastatin were given combined,<br/>renal function tests improved far more quickly than when the two medications were<br/>given separately. Conclusion: This study found that combination therapy improved renal<br/>function and controlled free radical production, inflammatory mediators, and histological<br/>alterations that lead to kidney injury. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15893 |
| Co-Author | Sen, Ashim Kumar |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-4-1091.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 12/01/2023 | 2023-0106 | 12/01/2023 | 12/01/2023 | Articles Abstract Database |