Study on solubility enhancement of etravirine by crystal engineering method (Record no. 18964)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20230316105526.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 230316b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14759 |
| Author | Bhattacharyya, Sayani |
| 245 ## - TITLE STATEMENT | |
| Title | Study on solubility enhancement of etravirine by crystal engineering method |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.84(3), May-Jun |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 575-585p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Etravirine, an antiretroviral agent, used in the treatment of human immunodeficiency virus belongs to<br/>biopharmaceutical classification system classification IV. The reported solubility of the drug is 0.0169 mg/<br/>ml. In the present study, an attempt was made to enhance the solubility of etravirine by crystal engineering<br/>technique. The cocrystallization method was carried out using 12 different coformers and each coformer<br/>was studied in two different stoichiometric ratios. A preliminary screening of all the cocrystals was done<br/>by determination of melting point and solubility. A statistical evaluation of all the cocrystals on solubility<br/>was carried out at a significance level of p<0.05. The best cocrystals were subjected to drug content, in vitro<br/>drug release, solid-state study (fourier transform infrared spectroscopy, differential scanning calorimetry,<br/>powder x-ray diffraction) and stability study for 3 mo. Coformer benzoic acid showed a significant<br/>improvement in etravirine solubility in the drug:coformer ratio of 1:1 and 1:2. The drug:benzoic acid<br/>ratio of 1:2 was found to have more solubility and showed enhanced dissolution compared to pure drug.<br/>The in vitro dissolution rate of the drug:benzoic acid ratio of 1:2 was found to be more than 90 % in 60<br/>min. Therefore, it can be concluded that the cocrystallization method with benzoic acid as coformer can be<br/>a promising approach for solubility improvement of etravirine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 20152 |
| Co-Author | Adhikari, H. |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0250-474X |
| Title | Indian journal of pharmaceutical sciences |
| Place, publisher, and date of publication | New Delhi Indian Pharmaceutical Association |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/a-study-on-solubility-enhancement-of-etravirine-by-crystal-engineering-method.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 16/03/2023 | 2023-0419 | 16/03/2023 | 16/03/2023 | Articles Abstract Database |