Inhibitory effect of polyphyllin d on proliferation of human colon cancer cell line sw480 via the microrna-21/phosphatase and tensin homolog deleted on chromosome 10 (Record no. 19422)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20230523155353.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 230523b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 20932 |
| Author | Zhang, Yu |
| 245 ## - TITLE STATEMENT | |
| Title | Inhibitory effect of polyphyllin d on proliferation of human colon cancer cell line sw480 via the microrna-21/phosphatase and tensin homolog deleted on chromosome 10 |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.84(4), Jul-Aug |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 874-882p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | To evaluate the effects of polyphyllin D on the proliferation and apoptosis of human colon cancer SW480<br/>cell lines and to reveal whether this process is mediated by the micro ribonucleic acid-21/phosphatase and<br/>tensin homolog deleted on chromosome 10 pathway. Human colon cancer SW480 cells were transfected<br/>with micro ribonucleic acid-21-mimic or mimic-negative control and treated with polyphyllin D at different<br/>concentrations (control, 0.25, 0.5, 1 and 2 μM) for 24 h or 48 h. Compared with control polyphyllin D group,<br/>the viability of human colon cancer SW480 cells significantly declined but the apoptosis rate significantly<br/>rose in 0.5 μM polyphyllin D group and the colony number of SW480 cells significantly decreased in 0.25 μM<br/>polyphyllin D group (p<0.05). Compared with control group, 2 μM polyphyllin D group had significantly<br/>increased protein expressions of Bcl-2 associated X protein and cleaved caspase-3, but decreased protein<br/>expression of B-cell lymphoma-2 in SW480 cells (p<0.001). The protein levels of micro ribonucleic acid-21<br/>and phosphorylated-protein kinase B in SW480 cells were significantly lower, while the phosphatase and<br/>tensin homolog deleted on chromosome 10 messenger ribonucleic acid and protein levels were higher in 2<br/>μM polyphyllin D group than those in control group (p<0.001). However, the protein expression of protein<br/>kinase B was not changed in 2 μM polyphyllin D group (p>0.05). After transfection with micro ribonucleic<br/>acid-21-mimic, the level of micro ribonucleic acid-21 in SW480 cells was significantly higher, while the<br/>phosphatase and tensin homolog deleted on chromosome 10 messenger ribonucleic acid and protein levels<br/>were significantly lower than those in control group (p<0.001). Compared with control group, the anti-<br/>proliferative and pro-apoptotic effects of polyphyllin D on SW480 cells were reversed by transfection<br/>with micro ribonucleic acid-2-mimic (p<0.001). Polyphyllin D inhibits proliferation and induces apoptosis<br/>of human colon cancer SW480 cells via the micro ribonucleic acid-21/phosphatase and tensin homolog<br/>deleted on chromosome 10 pathway. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17615 |
| Co-Author | Li, Zhang |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0250-474X |
| Place, publisher, and date of publication | New Delhi Indian Pharmaceutical Association |
| Title | Indian journal of pharmaceutical sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/inhibitory-effect-of-polyphyllin-d-on-proliferation-of-human-colon-cancer-cell-line-sw480-emviaem-the-microrna21phosphat.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 23/05/2023 | 2023-0844 | 23/05/2023 | 23/05/2023 | Articles Abstract Database |