Isolation of bioactive compounds from fruit body of lentinula edodes (berk.) pegler and in silico approach using tyrosinase target protein involved in melanin production (Record no. 19437)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20230524155345.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 230524b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 20956 |
| Author | Sharma, Diksha |
| 245 ## - TITLE STATEMENT | |
| Title | Isolation of bioactive compounds from fruit body of lentinula edodes (berk.) pegler and in silico approach using tyrosinase target protein involved in melanin production |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.84(4), Jul-Aug |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 1026-1040p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Traditionally, Lentinula edodes are used in many Asian countries for the treatment of various chronic<br/>diseases. In the current study, ethyl acetate fraction of fruit body of Lentinula edodes was obtained by<br/>standard bioassay-guided fractionation procedure. This fractionation resulted in the isolation of three<br/>bioactive compounds (compound 1 already reported, compound 2 and 3 first time reported from this<br/>mushroom) and their structures were characterized using various spectroscopic techniques. Further, all<br/>the compounds were studied using molecular docking analysis. Compounds 1, 2, 3 and standard active<br/>ingredient used for the treatment of hyperpigmentation i.e. arbutin was prepared as program database<br/>files, was docked with the target receptor (tyrosinase, program database ID: 5M8L) which plays a vital role<br/>in melanogenesis pathway. The study mainly focuses on better results of compounds as potent tyrosinase<br/>inhibitors to down-regulate the melanogenesis pathway. The present study revealed that due to the presence<br/>of compound 1 and 3 in the fruit body of Lentinula edodes, it may be preferred as a cosmetic product in<br/>extract form to obtain effective skin lightening properties or treatment of melisma. Compounds 2 and<br/>3 was first isolated from Lentinula edodes. The study further concludes that compound 3 could act as a<br/>potential lead molecule for the target gene tyrosinase with slight modification or optimization of chemical<br/>structure to obtain more effective, less toxic lead molecule and further exhibits remarkable skin lightening<br/>properties via inhibiting melanin production. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17574 |
| Co-Author | Singh, V. P. |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical sciences |
| Place, publisher, and date of publication | New Delhi Indian Pharmaceutical Association |
| International Standard Serial Number | 0250-474X |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/isolation-of-bioactive-compounds-from-fruit-body-of-emlentinula-edodesem-berk-pegler-and-in-silico-approach-using-tyrosi.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 24/05/2023 | 2023-0859 | 24/05/2023 | 24/05/2023 | Articles Abstract Database |