Factors affecting on in vitro release of miconazole from in situ ocular gel (Record no. 20618)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240118154609.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240118b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 22821 |
| Author | Al_Gawhari, Fatima Jalal |
| 245 ## - TITLE STATEMENT | |
| Title | Factors affecting on in vitro release of miconazole from in situ ocular gel |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.14(4), Oct-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Wolter Kluwer |
| Year | 2023 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 294-298p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The reason for conducting this study is to prolong release of miconazole in the ocular<br/>site of action by ocular‑based gels (OBGs) formulations. The formulation factors affecting<br/>on the release from OBG should be studied using various gelling agents in various<br/>concentrations to achieve the improvement in retention and residence time in response<br/>to prolonged release. In this study, the formulations were prepared using carbopol 940,<br/>pectin, sodium alginate, poloxamer 407, and poly(methacrylic acid) at 0.5%, 1%, and<br/>1.5% w/v, respectively. Hydroxypropyl methylcellulose E5 (HPMC E5) 1% was added as<br/>thickening agent/viscosity builder. The formulation containing carbopol 940, pectin and<br/>sodium alginate at 1.5% w/v, displayed a noticable improvement in viscosity, gelling<br/>capacity, and extended release for 7 h in comparison with the reference drug. Overall,<br/>the release showed that the sodium alginate with HPMC E5 form in situ gel which had<br/>longer time of release reach to 12 h compared with other polymers. the release of<br/>miconazole from the OBGs affected significantly by two factors includes gelling capacity<br/>and viscosity builder. The novelty of this study is supporting the delivery of ocular drugs<br/>through a cornea as an important key of the eye instead of dependence on an internal<br/>blood supply using an oral or a parental administration. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 2231-4040 |
| Title | Journal of advanced pharmaceutical technology and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10723164/pdf/JAPTR-14-294.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 18/01/2024 | 2024-0087 | 18/01/2024 | 18/01/2024 | Articles Abstract Database |