Genetic polymorphisms of GSTM1 and GPX1 genes and smoking susceptibility in the Saudi population (Record no. 20759)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240316103858.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240316b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 23028 |
| Author | Al-Zahrani |
| 245 ## - TITLE STATEMENT | |
| Title | Genetic polymorphisms of GSTM1 and GPX1 genes and smoking susceptibility in the Saudi population |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.15(4), Oct-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | ACC LTD |
| Year | 2023 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 180-189p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract<br/>Background/Objective/Methods: <br/><br/>Glutathione-S-transferase Mu1 (GSTM1) and glutathione peroxidase 1 (GPX1) are known antioxidant enzymes that help protect cells from the oxidative damage that occurs from smoking. This study explored the correlation between GSTM1 and GPX1 levels between a group of smokers with the GSTM1 and GPX1 genes in the Saudi population and a control group and investigated the genetic risk factors in the group of smokers.<br/>Results: <br/><br/>The control and smokers’ group (n = 50; aged 22.3 ± 3.1 years; BMI 24.6 ± 5.9 kg/m2) were genotyped using quantitative polymerase chain reaction (qPCR). In comparison with the control group, the smokers’ group displayed a different genotype disruption of GSTM1 and GPX1. Carriers of the homozygous (TT) genotype of GSTM1 had more than a twofold (OR = 2.71, 95% CI = 0.10–70.79, P = 1.000) smoking risk than the carriers of the heterozygous (CT) genotype. Those with the GPX1 gene showed no risk in the control and smokers’ groups. Smokers with the TT/GG combination (homozygous for GPX1 and normal for GPX1) were identified as high risk (OR = 2.58, 95% CI = 0.096–69.341).<br/>Conclusion: <br/><br/>The main outcomes showed no significant association between genetic polymorphism of the GSTM1 and GPX1 genes and cigarette smoking in the Saudi Arabian population. However, the results showed a slight decrease in the number of GSTM1 and GPX1 gene modifications among smokers.<br/> |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4762 |
| Topical term or geographic name entry element | BIOCHEMISTRY |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 23029 |
| Co-Author | Maryam Hassan |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of pharmacy and bio allied science |
| International Standard Serial Number | 0976-4879 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://journals.lww.com/jpbs/fulltext/2023/15040/genetic_polymorphisms_of_gstm1_and_gpx1_genes_and.3.aspx |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 16/03/2024 | 2024-0280 | 16/03/2024 | 16/03/2024 | Articles Abstract Database |