Ultraviolet spectrophotometric quantitation of anticancer drug alectinib hydrochloride in pharmaceutical formulation using green solvent (Record no. 22066)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250108120711.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250108b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 25003 |
| Author | Koradia, Shaileshkumar K. |
| 245 ## - TITLE STATEMENT | |
| Title | Ultraviolet spectrophotometric quantitation of anticancer drug alectinib hydrochloride in pharmaceutical formulation using green solvent |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.14(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Raipur |
| Name of publisher, distributor, etc. | Asian Pharma Press |
| Year | 2024 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 119-121p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The developed ultraviolet spectrophotometric method allows simple, eco- friendly, accurate and precise determination of anti-cancer agent alectinib hydrochloride in bulk and its pharmaceutical formulation. Alectinib hydrochloride standard drug was dissolved and quantitatively diluted in methanol to produced a solution of 8.0 µg/mL concentration and absorbance was measured at its detection wavelength 339 nm against methanol as reagent blank. The calibration curve obeyed Beer’s law in the concentration range of 2 - 12 µg/mL with correlation co-efficient of 0.9996. The detection limits and quantitation limits were found to be 0.57 µg/mL and 1.71 µg/mL, respectively which indicates method is sensitive. Precision experiment was for intra-day, inter-day and repeatability and %RSD was found to be within the specified limits. The percent recovery studies was performed at three different levels and was observed between 99.56 - 101.43 %, indicating insignificant interference from the other ingredients present in the capsule formulation. The robustness study was performed by deliberately variations in the method parameters and % RSD was calculated and found within the limits indicates that the method is robust. The method validation parameters such as accuracy, precision, linearity, detection limit and quantitation limit of were validated as per international council for harmonization guidelines Q2-R1 and successfully applied for the quantitative analysis of alectinib hydrochloride from its pharmaceutical formulation. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 25004 |
| Co-Author | Thakkar, Rushik P. |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 2231-5667 |
| Place, publisher, and date of publication | Raipur A & V Publications |
| Title | Asian journal of pharmaceutical analysis |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://ajpaonline.com/AbstractView.aspx?PID=2024-14-3-1 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 08/01/2025 | 2025-0006 | 08/01/2025 | 08/01/2025 | Articles Abstract Database |