Smart manipulated UV spectroscopic methods for resolving the overlapped spectra for quality control of two analgesic binary combination formulations (Record no. 22611)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250408094044.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250408b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 10005 |
| Author | Attimarad, Mahesh |
| 245 ## - TITLE STATEMENT | |
| Title | Smart manipulated UV spectroscopic methods for resolving the overlapped spectra for quality control of two analgesic binary combination formulations |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.58(3), Jul-Sep |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Bangalore |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2024 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 805-814p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The combination of two drugs celecoxib + tramadol and diclofenac sodium<br/>+ tramadol with different mechanisms of action is better for achieving effective pain control.<br/>Materials and Methods: The simple reproducible mathematically modified UV spectroscopic<br/>methods were established for concomitant evaluation of the binary combination of celecoxib<br/>+ tramadol and diclofenac sodium + tramadol formulations. The first technique is predicated<br/>on separating the pure zero-order spectra of TDL and CCB from the mixture spectra and<br/>quantification at their lambda max. The second and third method involves the ratio absorption<br/>difference and ratio first derivative spectroscopic method for quantification of DFS and TDL.<br/>Additionally, we followed ICH guidelines to validate these approaches for specificity, accuracy,<br/>and precision. Results: Both formulations were effectively analyzed using the proposed<br/>methods, with results falling into the series of 2-50 μg/mL for TDL, and 1-30 μg/mL for DFS and<br/>CCB. The good recovery of 98.56% -101.48% with low relative error and percentage relative<br/>standard deviation verified the methodologies' correctness and repeatability. Finally, proposed<br/>mathematically modified spectroscopic procedures were exploited for quality control of analytes<br/>from formulation and manually prepared mixtures. The determination of % of retrieval of an<br/>added known quantity of authentic medications of CCB, TDL, and DFS to the powdered pill served<br/>as additional evidence of correctness. Conclusion: The established UV spectroscopic techniques<br/>are simple, rapid, and perfect for simultaneous quantification of CCB, DSF, and TDL from the solid<br/>dosage forms. The assay results also confirmed the nonexistence of tablet adjuvants intervention<br/>in the quantification of medicines in the tablets Therefore, these approaches can be utilized for<br/>systematic quantification of these drugs in the binary formulations without chemical separation. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 25810 |
| Co-Author | Aldhubiab, Bandar |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://ijper.org/sites/default/files/IndJPhaEdRes-58-3s-805.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 08/04/2025 | 2025-0565 | 08/04/2025 | 08/04/2025 | Articles Abstract Database |