Valproic acid induced autism-like behaviour in zebrafish-chrysin as a miracle cure (Record no. 22700)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250423153329.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250423b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 25960 |
| Author | Dhanabal, Madhumitha |
| 245 ## - TITLE STATEMENT | |
| Title | Valproic acid induced autism-like behaviour in zebrafish-chrysin as a miracle cure |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.86(1), Jan-Feb |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Pharmacutical Association |
| Year | 2024 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 293-300p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Autism spectrum disorder belongs to a class of neurodevelopmental abnormality associated with complex behavioural traits and complications in social and cognitive performance. One in every hundred children has estimated to have autism according to the World Health Organisation. Therefore, research on the prognosis, diagnosis and therapy of autism spectrum disorder is the current need of the hour. Zebrafish as a model organism has enabled rapid advancements in neuroscience and biological psychiatry. Zebrafish behavioural characteristics can be used to understand the neuronal networks, physiological indicators and genetic basis of brain function. The search for neuroprotective medicines with fewer side effects has risen in popularity. Based on previous evidence, chrysin exhibited neuroprotective properties, inhibits neuro-inflammation and aids in the prevention of cognitive deterioration. In the present study, the neuroprotective role of chrysin was explored against valproic acid-induced autism spectrum disorder-like behaviour. The most efficient route of valproic acid administration was determined by testing two alternative techniques were immersion and intraperitoneal injection. The primary behavioural endpoints in autism spectrum disorder are learning, memory and social behaviour were studied via behavioural analysis. The findings imply that intraperitoneal injection is a more reliable method of induction when compared to immersion since the drug's uptake is reported to be uniform in all fish. According to the experimental data, chrysin positively stimulates on zebrafish social behaviour. More research is needed to fully comprehend the neurochemical pathways behind chrysin's effects on valproic acid-induced autism-like behaviour. Finally, our research supports the use of zebrafish models to investigate the neuroprotective benefits of drugs. From our findings, it is proven that chrysin could be used to alleviate valproic acid-induced autism-like behaviour. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 25961 |
| Co-Author | Brinda, Durai Raj |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | New Delhi Indian Pharmaceutical Association |
| Title | Indian journal of pharmaceutical sciences |
| International Standard Serial Number | 0250-474X |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/valproic-acid-induced-autismlike-behaviour-in-zebrafishchrysin-as-a-miracle-cure-5336.html |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 23/04/2025 | 2025-0649 | 23/04/2025 | 23/04/2025 | Articles Abstract Database |