Study of the correlation between expression of p-glycoprotein, livin, survivin and drug resistance in human gastric cancer cell line OCUM-2MD3/L-OHP (Record no. 22945)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250523110629.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250523b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 26367 |
| Author | Zhang, Jing |
| 245 ## - TITLE STATEMENT | |
| Title | Study of the correlation between expression of p-glycoprotein, livin, survivin and drug resistance in human gastric cancer cell line OCUM-2MD3/L-OHP |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.85(6), Nov-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2024 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 1690-1699p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | P-glycoprotein, livin, and survivin are apoptosis inhibitory proteins. This study was to clarify the correlation<br/>between expression of P-glycoprotein, livin, survivin, and drug resistance in the human gastric cancer<br/>resistant cell line OCUM-2MD3/oxaliplatin. The highly invasive metastatic gastric cancer cell line OCUM-<br/>2MD3 was utilized as experimental material. The oxaliplatin-resistant cell line, OCUM-2MD3/oxaliplatin,<br/>was established by inducing OCUM-2MD3 cells with oxaliplatin. Flow cytometry was employed to analyze the<br/>cell cycle and apoptosis of OCUM-2MD3/oxaliplatin cells. The sensitivity of OCUM-2MD3/oxaliplatin cells to<br/>drugs was determined using cell counting kit-8 assay. Real-time quantitative polymerase chain reaction and<br/>Western blot analysis were performed to determine the gene and protein expression levels of P-glycoprotein,<br/>livin, and survivin in OCUM-2MD3 and OCUM-2MD3/oxaliplatin cells, establishing the association between<br/>expression of these genes and proteins and drug resistance of OCUM-2MD3/oxaliplatin cells. Gene and<br/>protein expression levels of P-glycoprotein, livin, and survivin were markedly upregulated in OCUM-2MD3/<br/>oxaliplatin cells relative to OCUM-2MD3 cells. P-glycoprotein and livin expression exhibited a positive<br/>correlation with cisplatin resistance in OCUM-2MD3/oxaliplatin cells, whereas survivin expression showed<br/>a negative correlation with resistance. The expression levels of P-glycoprotein, livin, and survivin are closely<br/>associated with drug resistance in the human gastric cancer resistant cell line OCUM-2MD3/oxaliplatin. A<br/>theoretical basis was provided for development of novel therapeutic strategies targeting these molecules and<br/>contributes to enhancing clinical efficacy in gastric cancer patients. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 26368 |
| Co-Author | Zhang, L. |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0250-474X |
| Place, publisher, and date of publication | New Delhi Indian Pharmaceutical Association |
| Title | Indian journal of pharmaceutical sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/study-of-the-correlation-between-expression-of-pglycoprotein-livin-survivin-and-drug-resistance-in-human-gastric-cancer-.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 23/05/2025 | 2025-0901 | 23/05/2025 | 23/05/2025 | Articles Abstract Database |