Exploring cosolvency in analytical method development and validation of poorly aqueous soluble candesartan cilexetil in bulk and dosage forms (Record no. 23120)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250718151203.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250718b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 26771 |
| Author | Yadav, P. S. |
| 245 ## - TITLE STATEMENT | |
| Title | Exploring cosolvency in analytical method development and validation of poorly aqueous soluble candesartan cilexetil in bulk and dosage forms |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.86(2), Mar-Apr |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Pharmacutical Association |
| Year | 2024 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 195-201p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The study was performed with a dual approach to develop and validate analytical method for poorly water soluble candesartan cilexetil by enhancing its solubility employing cosolvency technique. In order to enhance drug’s solubility based on its solubility characteristics, phosphate buffer (pH 6.8):ethanol (95 % v/v) mixture at 90:10 proportion was used along with Tween 80 (1 % v/v). Solubility of candesartan cilexetil in phosphate buffer (pH 6.8) enhanced due to the addition of co-solvent ethanol and Tween 80. Developed method obeyed Beer-Lambert’s law in the concentration range between 3-21 μg/ml. The regression coefficient at the wavelength 232 nm was 0.999. The analysis of tablets by the proposed method indicated a good correlation between estimated and label claims. Recovery studies showed that any small difference in drug concentration could be accurately determined. Low values of limit of detection and limit of quantitation indicated that the proposed method is sensitive, economic, accurate, precise, and robust for routine analysis of candesartan cilexetil in bulk and dosage forms. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 4538 |
| Co-Author | Hajare, Ashok A. |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0250-474X |
| Title | Indian journal of pharmaceutical sciences |
| Place, publisher, and date of publication | New Delhi Indian Pharmaceutical Association |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/exploring-cosolvency-in-analytical-method-development-and-validation-of-poorly-aqueous-soluble-candesartan-cilexetil-in-.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 18/07/2025 | 2025-1036 | 18/07/2025 | 18/07/2025 | Articles Abstract Database |