Design and characterization of ph dependent phase transition system of almotriptan malate for nasal drug delivery system by employing factorial design (Record no. 23223)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250804102828.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250804b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 14912 |
| Author | Malviya, Vedanshu |
| 245 ## - TITLE STATEMENT | |
| Title | Design and characterization of ph dependent phase transition system of almotriptan malate for nasal drug delivery system by employing factorial design |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.58(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Bangalore |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2024 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 76-90p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Nasal medication delivery uses nasal mucosa for faster and higher drug absorption. Transmucosal nasal administration is promising. Many medicines obtain superior systemic absorption via nasal route than orally. Objectives: This research aimed to construct and characterize a pH-dependent almotriptan malate nasal in situ gel for acute migraine treatment. It eases discomfort, headaches, and migraine symptoms. Materials and Methods: Gels were delivered by changing the grouping of pH-sensitive and mucoadhesive polymers, explicitly HPMC-E15 and chitosan hydrochloride, in a cycle that was done by applying cool method Results. The range of drug content was between 95.87±0.45 to 99.58±0.56%. The pH value was measured to fall between 6.10±0.92 and 6.41±0.11. The obtained results notably agreed with the change in phase+transition, and the formulations portraits the rheology in a pseudoplastic behavior. This was a very exciting discovery. The mucoadhesiveness of all of the formulations rose with the HPMC-E15: Chitosan HCl concentration which was found to be in the range of 2133±1.58 to 3111.47±1.32 dynes/cm2 for the most effective formulations. The in vitro release of drug results of the optimized formulation, which consisted of 5 g HPMC-E15, 1 g Chitosan hydrochloride, and 1.5 g PEG400, indicated that 94.24±0.96% release occurred at the end of 12 hr. Studies using histopathology indicated that the AMF4 formulation had a non-toxic effect on the microscopic structure of the nasal mucosa when it was subjected to ex vivo permeation tests which showed the drug release of 78.85±0.87 %. Based on the findings of the stability research, a temperature range of 5ºC±3ºC is recommended for storing the formulations. Conclusion: As per these discoveries, nasal in situ gel containing almotriptan malate is probably going to turn into a selection of arrangements for treating migraines and other symptoms associated with migraines in the near future and in a nutshell, an in situ gel formulation of almotriptan malate that is pH dependent has the potential to function as an efficient method of treating migraines. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 26923 |
| Co-Author | Pande, Srikant |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://archives.ijper.org/article/2157 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 04/08/2025 | 2025-1222 | 04/08/2025 | 04/08/2025 | Articles Abstract Database |