Formulation, optimization and characterization of plga-chitosan nanoparticles containing vinorelbine ditartrate (Record no. 23225)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250804104833.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250804b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 26925 |
| Author | Bandil, Varsha |
| 245 ## - TITLE STATEMENT | |
| Title | Formulation, optimization and characterization of plga-chitosan nanoparticles containing vinorelbine ditartrate |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.58(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Banaglore |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2024 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 99-108p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: The prime objective of our investigation was to optimize PLGA-chitosan nanoparticles containing vinorelbine ditartrate. Materials and Methods: The Vinorelbine ditartrate nanoparticles were formulated using emulsion method followed by probe sonication to reduce the size. A three factor three level Box-Behnken Design has been implemented to optimize chitosan, Poloxamer 188 and sonication time (independent variables) for particle size, polydispersity index and entrapment efficiency (%) as the measured responses. Particle size, zeta potential, surface morphology, entrapment effectiveness, and in vitro drug release were all evaluated for the optimised formulation. Results: The optimized PLGA-chitosan nanoparticle exhibited particles size of 161.22 nm with polydispersity index of 0.229 and zeta potential value of 10.99 mV. The formulation exhibited 78.9% entrapment of vinorelbine ditartrate. The nanoparticle was able to sustain the release of vinorelbine for more than 140 hr in the in vitro release studies. Conclusion: From studying the obtained results, it could be concluded from the investigation that PLGA-chitosan nanoparticles could be good approach to improve the bioavailability of the entrapped drug. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 26908 |
| Co-Author | Gupta, Jeetendra Kumar |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://archives.ijper.org/article/2159 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 04/08/2025 | 2025-1224 | 04/08/2025 | 04/08/2025 | Articles Abstract Database |