Amelioration of lipid metabolic profiles by trigonelline a bioactive compound of trigonella foenum-graecum in alcohol induced albino rats (Record no. 23233)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250804154909.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250804b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 26935 |
| Author | Meesala, Guru Sekhar |
| 245 ## - TITLE STATEMENT | |
| Title | Amelioration of lipid metabolic profiles by trigonelline a bioactive compound of trigonella foenum-graecum in alcohol induced albino rats |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.58(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Bangalore |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2024 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 172-177p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: Alcoholism leads to heart diseases, lung diseases and liver disorders. Alcoholism impairs heart homeostasis and causes cardio vascular diseases. The current investigation was carried out to know the hypolipidemic effect of Trigonelline (TG) a bioactive compound of Trigonella foenum-graecum (TGf) in alcohol intoxicated rats. Materials and Methods: The rats were randomized into five groups and treatment was given as per the experimental protocol. The lipid metabolic profiles like Malondialdehyde (MDA), Total Cholesterol (TC), Triglycerides (TGs), High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL), Very-Low-Density Lipoprotein (VLDL), and liver markers Alkaline Phosphatase (ALP), Alanine Aminotransferase (AAT), Aspartate Aminotransferase (AST) were estimated in the serum of all experimental groups. Results: All the lipid metabolic profiles and AAT, AST, ALP elevated in alcohol treated group, except HDL. This may be due to the alterations in lipid metabolism, which leads to hypercholesterolaemia and alcohol induced liver damage. Whereas with trigonelline treatment in alcoholic rats, these lipid metabolic profiles and liver markers were normalized and came back to normal levels. Further histopathological observations also proved that trigonelline protected heart tissue from alcohol toxicity in rats. Conclusion: Our findings suggest that trigonelline modulated the lipid metabolic profiles in alcohol intoxicated rats, hence trigonelline might be effective for preventing or treating alcohol related disorders and lipid related diseases. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 18063 |
| Co-Author | Shanmugam, Kondeti Ramudu |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://archives.ijper.org/article/2166 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 04/08/2025 | 2025-1232 | 04/08/2025 | 04/08/2025 | Articles Abstract Database |