Spectrophotometric absorption correction methods for the estimation of fixed-dose combinations of dapagliflozin and metformin hydrochloride (Record no. 23246)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250805113125.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250805b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 26955 |
| Author | Dalal, Deepak |
| 245 ## - TITLE STATEMENT | |
| Title | Spectrophotometric absorption correction methods for the estimation of fixed-dose combinations of dapagliflozin and metformin hydrochloride |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.58(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Bangalore |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2024 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 291-296p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: For the assessment of fixed-dose combinations of Dapagliflozin and Metformin Hydrochloride in bulk pharmaceuticals and pharmaceutical formulations utilizing distilled water as a solvent, a novel, straightforward, precise, and accurate UV-spectrophotometric absorbance correction approach was devised. On the additive absorbance property, an absorbance correction method was based. Materials and Methods: By keeping Dapagliflozin and Metformin hydrochloride apart, a distinct spectrum was generated, displaying absorption maxima peaks (max) at 275nm (DAPA), and 245nm (MET). Compared to metformin hydrochloride, dapagliflozin displayed some absorbance at 275nm. At 245nm, both drugs exhibit absorption. A method for solving equations is based on measuring the absorbance of two wavelengths, 275nm, and 245nm. Exactly validating the procedure was done. Dapagliflozin and metformin hydrochloride concentration ranges of 2–10 µg/mL and 20–100 µg/mL, respectively, were used in the assays utilizing the absorbance correction method at 275nm and 245nm, respectively. Results: The mean recovery for each compound was 100.25 + 0.0459% and 99.82 + 0.059. The accuracy (RSD 2%) was discovered to be within bounds. This approach had precise and accurate optical properties. The proposed method can be used with pharmaceutical formulations, and it was unaffected by the usual excipients included in the formulation. Conclusion: The findings demonstrate that the method is practical for routine estimation of the fixed-dose combination of dapagliflozin and metformin hydrochloride, in a pharmaceutical dosage form. It is straightforward, conscious, accurate, and applicable. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 24731 |
| Co-Author | Kant, Ravi |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://archives.ijper.org/article/2180 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 05/08/2025 | 2025-1245 | 05/08/2025 | 05/08/2025 | Articles Abstract Database |