Differential effects of dexamethasone and rosiglitazone in a sephadex-induced model of lung inflammation in rats (Record no. 23720)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02215 a2200217 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20251204121209.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251204b |||||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Author | Nagar, Jignesh K. |
| 9 (RLIN) | 27673 |
| 245 ## - TITLE STATEMENT | |
| Title | Differential effects of dexamethasone and rosiglitazone in a sephadex-induced model of lung inflammation in rats |
| Remainder of title | :Possible role of tissue inhibitor of metalloproteinase-3 |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.47(2), Mar-Apr |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Wolter Kluwer |
| Year | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 153-159p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | To study the effects of two different classes of drugs in sephadex-induced lung inflammation using rats and explore the potential mechanism (s).<br/>Materials and Methods: <br/><br/>Effects of dexamethasone (0.3 mg/kg, p.o.) and rosiglitazone (10 mg/kg, p.o.) treatments were evaluated up to 3 days in sephadex challenged rats. 72 h postsephadex administration, broncho-alveolar lavage fluid (BALF) was collected for cell count and cytokine estimation. Lung tissues were harvested for gene expression and histopathology.<br/>Results: <br/><br/>Dexamethasone treatment resulted in significant inhibition of lymphocytes, monocytes, eosinophils and neutrophils, whereas rosiglitazone inhibited eosinophils and neutrophils only. Further, dexamethasone reduced the elevated levels of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) after sephadex challenge while rosiglitazone significantly reduced the PGE2 levels without altering LTB4 in the BALF. Hydroxyproline content in rat lung homogenate was significantly reduced with dexamethasone treatment but not with rosiglitazone. Both the drugs were found to suppress matrix metallo proteinase 9, whereas only dexamethasone showed inhibition of tumor necrosis factor-alpha and up-regulation of tissue inhibitor of metalloproteinase 3 (TIMP-3) expression and preserved the broncho-alveolar microstructure. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | PHARMACOLOGY |
| 9 (RLIN) | 4774 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Co-Author | Patel, Praful P. |
| 9 (RLIN) | 27649 |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Andheri - Mumbai Wolters Kluwer India Private Limited |
| Title | Indian Journal of Pharmacology |
| International Standard Serial Number | 0253-7613 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://journals.lww.com/iphr/fulltext/2015/47020/differential_effects_of_dexamethasone_and.5.aspx |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 04/12/2025 | 2025-1752 | 04/12/2025 | 04/12/2025 | Articles Abstract Database |