Inhibition of Aromatase and Cell Proliferation of Breast Cancer and Human Placenta Choriocarcinoma by Prunus persica Extracts (Record no. 7965)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20190314111533.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 181224b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 7166 |
| Author | Dhingra, N. |
| 245 ## - TITLE STATEMENT | |
| Title | Inhibition of Aromatase and Cell Proliferation of Breast Cancer and Human Placenta Choriocarcinoma by Prunus persica Extracts |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol. 80(05), September-October |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Year | 2018 |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 903-910 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Prunus persica has been used as a source of traditional medicine in many countries for the treatment of different diseases in females. In the present study, cytotoxicity and reactive oxygen species scavenging effects of Prunus persica extract on human breast cancer and placenta choriocarcinoma cell lines were evaluated. Besides this, regulations of oestrogen synthesis and antiaromatase activity were observed on human placenta choriocarcinoma cells. Ethyl acetate and butanol fractions had the maximum cytotoxic activity among all the fractions. In comparison to butanol fraction, ethyl acetate fraction was found to scavenge maximum intracellular reactive oxygen species, which was correlated with its total phenolic and flavonoid contents. Ethyl acetate was found to reduce the aromatase activity by 50 % at the concentration of 200 µg/ml. This inhibitory effect on aromatase was accompanied by reduced 17β-estradiol levels in JEG-3 cells. It seemed that the ethyl acetate and n-butanol fractions of Prunus persica or its active compound appears to be acting through dual mechanisms, i.e. improvement of antioxidant system and by suppressing aromatase; it may potentially be used as therapeutic agent for the treatment of breast cancer. These findings suggested that Prunus persica extract could be an aromatase inhibitor for the treatment of oestrogen-sensitive breast cancer. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4755 |
| Topical term or geographic name entry element | PHARMACOGNOSY |
| 653 ## - Keywords | |
| Keywords | Oestrogen synthesis |
| 653 ## - Keywords | |
| Keywords | ROS scavenging |
| 653 ## - Keywords | |
| Keywords | Breast cancer |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 7168 |
| Co-Author | Kar, A. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 7169 |
| Co-Author | Sharma, R. |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0250-474X |
| Place, publisher, and date of publication | New Delhi Indian Pharmaceutical Association |
| Title | Indian journal of pharmaceutical sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Link text | Click here |
| URL | http://www.ijpsonline.com/articles/inhibition-of-aromatase-and-cell-proliferation-of-breast-cancer-and-human-placenta-choriocarcinoma-by-iprunus-persicai-extracts-3545.html |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 29/03/2019 | 2018265 | 19/06/2019 | 29/03/2019 | Articles Abstract Database |