Synthesis and Preliminary Antiproliferative Activity of Novel 4-Substituted Phenylsulfonyl Piperazines with Tetrazole Moiety (Record no. 7980)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20190314111845.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 181226b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 7187 |
| Author | Kommula, D. |
| 245 ## - TITLE STATEMENT | |
| Title | Synthesis and Preliminary Antiproliferative Activity of Novel 4-Substituted Phenylsulfonyl Piperazines with Tetrazole Moiety |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol. 80(05), September-October |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumabi |
| Year | 2018 |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 930-939 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | A series of 1-substituted-1H-tetrazole-5-thiol building blocks were synthesized (6a–h) and coupled by S-alkylation with 2-bromo-1-(4-(substituted phenylsulfonyl)piperazin-1-yl)ethanone (4a–c) using triethylamine in ethanol under reflux conditions. The structures of newly synthesized compounds were characterised by nuclear magnetic resonance and mass spectral data. Further, the hybrid compounds (7a–x) were screened for in vitro inhibitory effect on human cervical carcinoma (SiHA), breast adenocarcinoma (MDA-MB-235) and human pancreatic carcinoma (PANC-1) cell lines using sulforhodamine B assay. Antiproliferative assay revealed that most of the target compounds exhibited significant growth inhibitory activity (GI50≤0.1 µM) against all tested cancer cell lines compared to the reference drug. The most promising active compounds in this series were 7e and 7n, which displayed antiproliferative activity with GI50≤0.2 µM against the SiHa and MIDA-MB-231 cancer cell lines, whereas compounds 7g, 7l, 7p, 7s and 7t exhibited antiproliferative activity with GI50≤0.1 µM against the PANC-1 cell line. Thus the tetrazole-piperazinesulfonamide hybrid compounds could be potential leads for the development of new antiproliferative agents. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 653 ## - Keywords | |
| Keywords | Hybrid |
| 653 ## - Keywords | |
| Keywords | Antiproliferative activity |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 7188 |
| Co-Author | Polepalli, Sowjanya |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 7189 |
| Co-Author | Jain, N. |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | New Delhi Indian Pharmaceutical Association |
| International Standard Serial Number | 0250-474X |
| Title | Indian journal of pharmaceutical sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Link text | Click here |
| URL | http://www.ijpsonline.com/articles/synthesis-and-preliminary-antiproliferative-activity-of-novel-4substituted-phenylsulfonyl-piperazines-with-tetrazole-moiety-3548.html |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 29/03/2019 | 2018338 | 19/06/2019 | 29/03/2019 | Articles Abstract Database |