Development of a simple and sensititive HPLC method for the determination of rifaximin in serum and its application (Record no. 8498)
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| 000 -LEADER | |
|---|---|
| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20190315101324.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190312b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 7994 |
| Author | Hossain, M. A. |
| 245 ## - TITLE STATEMENT | |
| Title | Development of a simple and sensititive HPLC method for the determination of rifaximin in serum and its application |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol. 80(6), November-December |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Year | 2018 |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 1108-1114 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Rifaximin, a virtually non-absorbed rifamycin drug is gaining attention for its broad-spectrum of activity. A couple of methods have been reported for its determination in biological matrices. However, inconvenient sample preparation procedure, lack of sensitivity and long analysis time hindered the application of those methods in pharmacokinetic and toxicological study. Thus, a high performance liquid chromatography method has been developed and validated in this study for the sensitive quantification of rifaximin in serum. In this procedure, chromatographic separation was achieved by flowing a mobile phase comprise of acetonitrile and 0.1 % acetic acid (60:40, v/v) through a C18 column (150×4.6 mm, 5 μm). An ultraviolet detector was utilized to identify and quantify the compound. The method has been validated over a concentration range of 0.03-30.00 μg/ml (r2=0.9999) by utilizing 150 μl of serum. The accuracy of the method was 89.59-98.84 %, and the intra- and inter-day precisions were 0.41-6.84 and 1.83-5.71 %, respectively. The compound was stable in different storage conditions. Insignificant amounts (2.40±0.38 to 4.22±1.10 μg/ml) of rifaximin were quantified in serum samples of rat from 2 to 8 h after oral administration. This method offers a rapid, sensitive, specific, reproducible, and stable tool for the quantitative determination of rifaximin in serum, which could be applicable in other biological matrices and species for pharmacokinetic and toxicological study of rifaximin. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 7995 |
| Co-Author | Pervin, Rokeya |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 7996 |
| Co-Author | Park, Na-Hye |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0250-474X |
| Title | Indian journal of pharmaceutical sciences |
| Place, publisher, and date of publication | New Delhi Indian Pharmaceutical Association |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | http://www.ijpsonline.com/articles/development-of-a-simple-and-sensitive-hplc-method-for-the-determination-of-rifaximin-in-serum-and-its-application-3570.html |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 30/03/2019 | 2018450 | 19/06/2019 | 30/03/2019 | Articles Abstract Database |