Pharmacokinetics and Tissue Distribution of PLGA-PLL-PEG-TF Nanoparticles Loaded with Daunorubicin and Tetrandrine Following Intravenous Injection in the Rats Using LC-MS/MS (Record no. 9778)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20191019102129.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191019b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 9975 |
| Author | Wang, Yonglu |
| 245 ## - TITLE STATEMENT | |
| Title | Pharmacokinetics and Tissue Distribution of PLGA-PLL-PEG-TF Nanoparticles Loaded with Daunorubicin and Tetrandrine Following Intravenous Injection in the Rats Using LC-MS/MS |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.52(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Indian journal of pharmaceutical education and research |
| Year | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 42-53p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: A sensitive, rapid and reliable LC-MS/MS method was developed for simultaneously determination of daunorubicin (DNR) and tetrandrine (Tet) in rat plasma and tissues. Methods: The pharmacokinetics and tissue distribution of DNR/Tet-PLGA-PLL-PEG-NPs-Tf (D/T-PPP-NPs-Tf), DNR/Tet-PLGA-PLL-PEG-NPs (D/T-PPP-NPs) and DNR/Tet (D/T) solution were compared following intravenous injection in the rats. Result: Compare to D/T solution, the parameters of DNR and Tet in D/T-PPP-NPs-Tf group presented significantly higher AUC (p<0.01) and lower V (p<0.05). Compared with D/T solution, the distribution of DNR in groups of D/T-PPP-NPs and D/T-PPP-NPs-Tf were higher in liver (p<0.01), lung (p<0.05), fat (p<0.05) and testicle (p<0.05), and were lower in heart, spleen, kidney (p<0.01), brain and intestine (p<0.01). The distribution of Tet in D/T-PPP-NPs and D/T-PPP-NPs-Tf groups were higher in liver, brain and uterus (p<0.05), and were lower in heart, spleen, lung, kidney and fat (p<0.05) compared with D/T solution. Conclusion: The LC-MS/MS method was specific, sensitive, rapid and reliable for the simultaneously determination of DNR and Tet in rat plasma and tissues. Compared with D/T solution, D/T-PPP-NPs-Tf tended to stay in the blood after injection. The distribution of D/T-PPP-NPs and D/T-PPP-NPs-Tf were significantly changed. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 9976 |
| Co-Author | Li, Yang |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes_52_1_42.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 19/10/2019 | 2019931 | 19/10/2019 | 19/10/2019 | Articles Abstract Database |