Pharmaceutical Formulation and Biochemical Evaluation of Atorvastatin Transdermal Patches (Record no. 9779)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20191019104803.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191019b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 9978 |
| Author | Shehata, Tamer M. |
| 245 ## - TITLE STATEMENT | |
| Title | Pharmaceutical Formulation and Biochemical Evaluation of Atorvastatin Transdermal Patches |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.52(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Indian journal of pharmaceutical education and research |
| Year | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 54-61p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Atorvastatin is a lipid lowering agent and widely used to treathypercholestermia. However following oral administration, the bioavailability of thedrug is only 12% due to extensive first pass metabolism. The aim of the current researchwas to formulate ATO- transdermal patches utilizing various polymers combinations. Hydroxypropyl methylcellulose with either eudragit RS100 or Polyvinylpyrrolidone were mixed in different ratios, in presence of polyethylene glycol 400 as plasticizer. The patches were prepared by solvent evaporation method. Physicomechanical parameters such as, drug content, patch thickness, tensilestrength, moisture loss and moisture gained were evaluated. Additionally drug excipient compatibility was assessed by FTIR and DSC. In vitro drug release was measured in phosphate buffer pH 7.4 at 37 °C. Finally,biochemical evaluation of the best formulae was evaluated on hyperlipidemic-induced rats. The results indicated that, Hydroxypropyl methylcellulose: Polyvinylpyrrolidone in a ratio of 3:1 showed the most appropriate physicomechanical characters with confirmed physical and chemical drug-polymer compatibility. In addition, the in-vitro experiment showed enhanced atorvastatin release over 24 hr. The pharmacological evaluation of F2 formula indicated a significant hypolibedimic effect compared to orally administered atorvastatin. The results revealed that, atorvastatin transdermal patch could be considered as promising drug delivery system for hyperlipidemic patients. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 9979 |
| Co-Author | Omar M.M. Mohafez |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number | 0019-5464 |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes_52_1_54.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 19/10/2019 | 2019932 | 19/10/2019 | 19/10/2019 | Articles Abstract Database |