Effect of Canscora decussata Extract against the Neurochemical and Behavioral Changes Induced by 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine in Mice (Record no. 9785)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220825093438.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191019b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 9990 |
| Author | Chitra V. |
| 245 ## - TITLE STATEMENT | |
| Title | Effect of Canscora decussata Extract against the Neurochemical and Behavioral Changes Induced by 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine in Mice |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.52(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Indian journal of pharmaceutical education and research |
| Year | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 87-93p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced parkinsonism is a widely accepted animal model for screening the drugs used in Parkinson’s disease (PD). In the present study, the neuroprotective effects of methanolic extract of Canscora decussata(MECD) were evaluated, which was already known for its monoamine oxidase inhibiting, antidepressant and anticonvulsant activities, a part from its use as a nerve tonic. Materials and Methods: Twenty four male Swiss albino mice were grouped into 4 (n=6). MECD at 100 and 200 mg/kg doses, 30 minutes before the MPTP (20 mg/kg, intraperitoneal administration) treatment were administered for 7 days and behavioral assessment was made by rota rod test, grip strength test, spontaneous locomotor activity and catatonia behavioral study. In addition, assessment of antioxidant enzymes such as SOD, CAT, GPx and GSH was done to know the neurotoxicity of MPTP. Results:The results indicated that MECD shows a significant improvement (*P<0.05) in the behavioral activities, striatal neurotransmitter content and antioxidant status in a dose dependent manner and significantly (P<0.05) decreased the TBARS levels. Conclusion:The results obtained in this study indicate the antioxidant and neuroprotective role of MECD. Hence, Canscora decussata seems to have anti-Parkinson’s activity in mice.Key words: Parkinson’s disease, Canscora decussata, Substantia nigra, Dopamine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 9992 |
| Co-Author | Tamilanban T. |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0019-5464 |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title | Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes_52_1_87.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | School of Pharmacy | School of Pharmacy | Archieval Section | 19/10/2019 | 2019938 | 19/10/2019 | 19/10/2019 | Articles Abstract Database |