Drug Stereochemistry: Analytical Methods and Pharmacology, Third Edition covers all aspects of chiral drugs from academic, governmental, industrial, and clinical perspectives, reflecting the many advances in techniques and methodology.

Topics include:

The use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug discovery

How stereochemistry impacts decisions made in the absorption, distribution, metabolism, excretion, and toxicity (ADMET) stages of drug discovery

Pharmacokinetics and pharmacodynamics and the issues faced during the final stages of the drug development process

The impact of the International Conference on Harmonisation (ICH) on the use of single isomer drugs

Chiral switches

The concept of molecular chiral recognition and how it affects the separation and behavior of stereochemically pure drugs

Patent issues surrounding chiral switches and the marketing of single enantiomer switches The book provides a solid background on stereochemistry, from its early history, including an overview of terms and concepts, to the current drug development process, legal and regulatory issues, and the new stereoisomeric drugs. It is a one-stop reference for pharmaceutical scientists and chemists working with chiral drug molecules.

Table of Contents

INTRODUCTION
The early history of stereochemistry: From the discovery of molecular asymmetry and the first resolution of a racemate by Pasteur to the asymmetrical chiral carbon of van’t Hoff and Le Bel, Dennis E. Drayer
Stereochemistry—basic terms and concepts, Krzysztof Jo´z´wiak
Molecular basis of chiral recognition, Krzysztof Jo´z´wiak

PART II: THE SEPARATION, PREPARATION, AND IDENTIFICATION OF
STEREOCHEMICALLY PURE DRUGS
Separation and resolution of enantiomers and their dissociable diastereomers through direct crystallization, Harry G. Brittain
Indirect methods for the chromatographic resolution of drug enantiomers, Władysław Gołkiewicz and Beata Polak
HPLC chiral stationary phases for the stereochemical resolution of enantiomeric compounds: The current state of the art, W. John Lough
Preparative and production scale chromatography in enantiomer separations, Geoffrey B. Cox
Enantioselective separations by electromigration techniques, Michał J. Markuszewski
Alternative analytical techniques for determination or isolation of drug enantiomers, W. John Lough

PART III: PHARMACOKINETIC AND PHARMACODYNAMIC
DIFFERENCES BETWEEN DRUG STEREOISOMERS
Stereoselective transport of drugs, Prateek Bhatia and Ruin Moaddel
Enantioselective binding of drugs to plasma proteins, Thomas H. Kim
Clinical pharmacokinetics and pharmacodynamics of stereoisomeric drugs, Scott A. Van Wart and Donald E. Mager

PART IV: PERSPECTIVES ON THE DEVELOPMENT AND USE OF SINGLE
ISOMER DRUGS
Regulatory perspective on the development of new stereoisomeric drugs, Sarah K. Branch and Andrew J. Hutt
Molecular analysis of agonist stereoisomers at b2-adrenoceptors, Roland Seifert and Stefan Dove
Development of chiral drugs from a U.S. legal patentability perspective:Enantiomers and racemates, Svetlana M. Ivanova
The importance of chiral separations in single enantiomer patent cases, Charlotte Weekes