Objective:
Chlorpheneramine maleate is a first-generation anti
histamine drug used in the treatment of allergic co
nditions like rhinitis, urticaria,
and cough cold, etc. In present work, the challenge
has been made to develop an orally disintegrating
tablet of chlorpheneramine maleate with an
increase in bioavailability and patient compliance.
Methods:
The sublimation technique was used to prepare orall
y disintegrating tablets. Porous tablet prepared af
ter sublimation of camphor at 60
°C in a hot air oven for 60 min. In the research wo
rk, 3
2
full factorial design used to find out the effect o
f two variables like the amount of
Crospovidone and Croscarmellose sodium.
Results:
All prepared formulations were analyzed for various
parameters. DSC of pure drug and optimized formula
tion A (9) showed purity of sample and
compatibility of all ingredients with each other. I
n FTIR study of pure drug and optimized formulation
A (9) no major shifts were seen. An optimized
formulation (A9) was found to have good hardness (3
.2 kg/cm2), friability (<1 %), disintegration time
(26 s), % drug release (99.77 %) within 6 min.
Conclusion:
The result obtained showed that orally disintegrati
ng tablet of chlorpheneramine maleate enhances diss
olution rate, improves
bioavailability which will improve patient complian
ce.