Objective:
The aim of
present
study
was to prepare nano
structured lipid carriers (NLCs
) based Triamcinolone acetonide
(TA)
.
Method
s:
Nanostructured
lipid carriers (NLC
s) consisted of solid
lipid and liquid lipid are a new type of lipid nanoparticles,
prepared
by using
solvent diffusion and high
pressure homogenization methods
, which offer the advantage of improved drug loading capacity and release properties.
Glyceryl
monostearate
selected
as the solid lipid, c
apmul MCM C8 as the liquid lipid, p
olyvinyl Alcohol (PVA)
as the surfactant. NLCs
dispersion was
characterized by
particle size analysis,
zeta potential, scanning electron microscopy
(SEM)
, differential scanning calorimetry, and an
in
vitro
release
study.
Result
s:
Optimized NLCs loaded with TA were
exhibited spherical shape with particle size 286.
1 nm
, polydispersity index
0.317
, zeta potential
-21.9
mV and entrapment
efficiency
86.19
%
respectively
. The result of
differential scanning c
alorimetry
(DSC
) showed that drug was dispersed in NLC
s in
a crystalline state.
In vitro
release studies revealed that
drug release of
optimized
batch was 8.34
%
and
88.84
% at
1h
and
8h respectively. The
release kinetics of the optimized NLC
s best fitted the p
eppas
-korsmeyer model.
Furthermore, morphological investigations by SEM showed that
optimized batch exhibit a spherical shape and a smooth surface.
Conclusio
n:
Thus,
the
results indicated that
successfully prepared TA-
loaded
NLC
s and
could potentially be exploited as a carrier with improved
drug loading capacity and sustained
drug release.
The p
resent results demonstrated that these systems could be a promising platform for
inflammatory diseases, in particular for psoriasis topical th
erapy.