Development and Validation of UPLC method for the determination of Lenvatinib in Capsule formulation
Publication details: Raipur Asian Pharma Press 2019Edition: Vol.9(4), Oct-DecDescription: 249-252pSubject(s): Online resources: In: Asian journal of pharmaceutical researchSummary: A new, simple and selective method was developed to estimate Lenvatinib pharmaceutical dosage form by UPLC. Ideal Chromatographic peak of separation was attained on a Acquity BEH C18 (50*3.0mm. 1.7µm) using mobile phase consisting 0.1% Orthophosphoric acid: ACN (60:40) v/v with detection of 248 nm. Linearity of the drug was observed in the concentration range 60-140 µg /ml (r2 =0.994). From the results, the developed method was simple, sensitive, precise and accurate and it can successfully be applied for the determination of API in the commercial formulations of Lenvatinib in quality control laboratories.| Item type | Current library | Status | Barcode | |
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School of Pharmacy Archieval Section | Not for loan | 2020-2021167 |
A new, simple and selective method was developed to estimate Lenvatinib pharmaceutical dosage form by UPLC. Ideal Chromatographic peak of separation was attained on a Acquity BEH C18 (50*3.0mm. 1.7µm) using mobile phase consisting 0.1% Orthophosphoric acid: ACN (60:40) v/v with detection of 248 nm. Linearity of the drug was observed in the concentration range 60-140 µg /ml (r2 =0.994). From the results, the developed method was simple, sensitive, precise and accurate and it can successfully be applied for the determination of API in the commercial formulations of Lenvatinib in quality control laboratories.
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