Objective:Aim of the present study was to compare the effectsof pregabalinand nortriptyline onsleep and qualityof life in patients of postherpetic neuralgia (PHN).Methods: The present study was conducted in48patients of PHN attending the outpatient department (OPD)of Dermatology, Government Medical College Jammu. Based oninclusion/exclusion criteria patients were randomized into two treatment groups.One group received pregabalin 150 mg/day and the other group was treated with nortriptyline25 mg/day. The patientswere followed upto eightweeks and assessed for Sleep (Medical Outcomes Study sleep scale)and quality of life (Euro QOL-5D-5L score). Clinicians Global Impression of Change (CGIC)scoreand Patient Global Impression of Change(PGIC)score were used toevaluate overall clinical improvement.Results:Both drugs significantly improved all parametersstudied (p<0.0001).On comparison,both drugs had similar effectson sleep and quality of life.However, pregabalinwas found to be better than nortriptyline at eight weeksonCGIC (p<0.004) and PGIC (p<0.0003)scores.Conclusion:Both pregabalin and nortriptyline wereequallyeffectivein improving sleep and quality of life.Overall clinical improvement was better with pregabalin than nortriptyline at eight weeks