Viral infections are posing a great threat to humanity for the last few years. Among these, Chikungunya which
is a mosquito‑borne viral infection has produced enormous epidemics around the world after been rebounded.
Although this infection shows a low mortality rate, patients suffer from fever, arthralgia, and maculopapular
rashes, which reduce the quality of life for several weeks to years. The currently available treatments only
provide symptomatic relief based on analgesics, antipyretics, and anti‑inflammatory drugs which are nonspecific
without satisfactory results. Medicinal plants are a widely accepted source of new molecules for the treatment of
infectious diseases including viral infections. The scientific reports, primarily focusing on the anti‑chikungunya
activity of plant extracts, natural origin pure compounds, and their synthetic analog published from 2011 to 2021,
were selected from PubMed, Google Scholar, and Scopus by using related keywords like anti‑chikungunya
plants, natural antivirals for Chikungunya. The present review decodes scientific reports on medicinal plants
against chikungunya virus (CHIKV) infection and demystifies the potential phytoconstituents which reveals
that the screening of flavonoids containing plants and phytochemicals showing efficacy against other arbovirus
infections, may prove as a potential lead for drug development against CHIKV. The present article also outlines
pathogenesis, clinical aspects, molecular virology, and diagnostic approaches of CHIKV infection.